Recent advances in improved efficacies of gold nano-formulations in treatment of skin cancer: a systematic review

IF 1.8 4区医学 Q3 DERMATOLOGY

Archives of Dermatological Research Pub Date : 2025-01-20 DOI:10.1007/s00403-025-03817-8

Mohammadbagher Heydari, Mehrdad Saifi, Maryam Ghanbari-Movahed, Nader Salari, Sayed Hassan Faghihi, Masoud Mohammadi

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引用次数: 0

Abstract

Skin cancer is the commonest malignancy for the population. Conventional skin cancer treatments include chemotherapy and surgery, but a large number of the chemotherapeutic drugs applied currently have undesirable possessions. The aim of this study is to provide a complete and acute assessment of the antitumor capability of gold nano-formulations in skin cancer as a new and more effectual delivery system for targeted therapy. In this systematic review, we conducted our first search in December 2021. In order to find related studies, 3 databases PubMed, Scopus and ScienceDirect. In order to maintain comprehensiveness in the search, no time limit was considered in the search process and finally the information obtained from the search was transferred to the information management software (EndNote). In order to maximize the number of articles that were related to our topic, a list of references identified in relevant articles was also manually searched and reviewed. Our final search was updated in late December 2021. There was evidence for a correlation between anticancer activities and treatment with gold nano-formulations. Additionally, studies shown that specific functionalization of the gold nanoparticles (Au NPs) which increase targetability to specific populations of cells could increase the application of Au NPs to the effective delivery of drugs to tumor cells. Our study demonstrated that gold nano-formulations are possible candidates for skin cancer treatment and might provide additional support for the clinical use of these anticancer agents in the future.

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金纳米制剂治疗皮肤癌疗效的最新进展：系统综述

皮肤癌是人类最常见的恶性肿瘤。传统的皮肤癌治疗方法包括化疗和手术，但目前大量使用的化疗药物存在不良成分。本研究的目的是对金纳米制剂作为一种新的、更有效的靶向治疗递送系统在皮肤癌中的抗肿瘤能力进行全面和急性的评估。在本系统综述中，我们于2021年12月进行了第一次搜索。为了找到相关研究，检索了PubMed、Scopus和ScienceDirect 3个数据库。为了保持搜索的全面性，在搜索过程中不考虑时间限制，最后将搜索得到的信息传输到信息管理软件（EndNote）中。为了最大限度地增加与我们主题相关的文章的数量，我们还手动搜索和审查了相关文章中识别的参考文献列表。我们的最终搜索于2021年12月底更新。有证据表明，抗癌活性与金纳米制剂治疗之间存在相关性。此外，研究表明，金纳米颗粒（Au NPs）的特异性功能化增加了对特定细胞群体的靶向性，可以增加金纳米颗粒在有效向肿瘤细胞递送药物方面的应用。我们的研究表明，金纳米制剂可能是皮肤癌治疗的候选者，并可能为将来这些抗癌药物的临床应用提供额外的支持。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Archives of Dermatological Research 医学-皮肤病学

CiteScore

4.10

自引率

3.30%

发文量

审稿时长

4-8 weeks

期刊介绍： Archives of Dermatological Research is a highly rated international journal that publishes original contributions in the field of experimental dermatology, including papers on biochemistry, morphology and immunology of the skin. The journal is among the few not related to dermatological associations or belonging to respective societies which guarantees complete independence. This English-language journal also offers a platform for review articles in areas of interest for dermatologists and for publication of innovative clinical trials.