Phospholipase C epsilon 1 as a therapeutic target in cardiovascular diseases

IF 11.4 1区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Journal of Advanced Research Pub Date : 2025-01-22 DOI:10.1016/j.jare.2025.01.032

Jie Wang, Ting Gao, Dongmei Zhang, Yufeng Tang, Junlian Gu

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引用次数: 0

Abstract

Background

Phospholipase C epsilon 1 (PLCε1) can hydrolyze phosphatidylinositol-4,5-bisphosphate and phosphatidylinositol-4-phosphate at the plasma membrane and perinuclear membrane in the cardiovascular system, producing lipid-derived second messengers. These messengers are considered prominent triggers for various signal transduction processes. Notably, diverse cardiac phenotypes have been observed in cardiac-specific and global Plce1 knockout mice under conditions of pathological stress. It is well established that the cardiac-specific Plce1 knockout confers cardioprotective benefits. Therefore, the development of tissue/cell-specific targeting approaches is critical for advancing therapeutic interventions.

Aim of Review:

This review aims to distill the foundational biology and functional significance of PLCε1 in cardiovascular diseases, as well as to explore potential avenues for research and the development of novel therapeutic strategies targeting PLCε1.

Key Scientific Concepts of Review:

Cardiovascular diseases remain the leading cause of morbidity and mortality worldwide, with incidence rates escalating annually. A comprehensive understanding of the multifaceted role of PLCε1 is essential for enhancing the diagnosis, management, and prognostic assessment of patients suffering from cardiovascular diseases.

Abstract Image

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磷脂酶cepsilon 1作为心血管疾病的治疗靶点

磷脂酶Cε1 （PLCε1）在心血管系统的质膜和核周膜上水解磷脂酰肌醇-4,5-二磷酸和磷脂酰肌醇-4-磷酸，产生脂质衍生的第二信使。这些信使被认为是各种信号转导过程的突出触发器。值得注意的是，在病理应激条件下，在心脏特异性和全局Plce1敲除小鼠中观察到不同的心脏表型。众所周知，心脏特异性Plce1敲除具有心脏保护作用。因此，组织/细胞特异性靶向方法的发展对于推进治疗干预至关重要。综述目的：本文旨在总结PLCε1在心血管疾病中的基础生物学和功能意义，并探索针对PLCε1的研究和开发新的治疗策略的潜在途径。综述的主要科学概念：心血管疾病仍然是世界范围内发病率和死亡率的主要原因，发病率每年都在上升。全面了解PLCε1的多方面作用对于加强心血管疾病患者的诊断、管理和预后评估至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Advanced Research Multidisciplinary-Multidisciplinary

CiteScore

21.60

自引率

0.90%

发文量

280

审稿时长

12 weeks

期刊介绍： Journal of Advanced Research (J. Adv. Res.) is an applied/natural sciences, peer-reviewed journal that focuses on interdisciplinary research. The journal aims to contribute to applied research and knowledge worldwide through the publication of original and high-quality research articles in the fields of Medicine, Pharmaceutical Sciences, Dentistry, Physical Therapy, Veterinary Medicine, and Basic and Biological Sciences. The following abstracting and indexing services cover the Journal of Advanced Research: PubMed/Medline, Essential Science Indicators, Web of Science, Scopus, PubMed Central, PubMed, Science Citation Index Expanded, Directory of Open Access Journals (DOAJ), and INSPEC.