Aldolase A: the broker of glycolysis

IF 18.9 1区医学 Q1 ENDOCRINOLOGY & METABOLISM

Nature metabolism Pub Date : 2025-01-20 DOI:10.1038/s42255-024-01202-9

Luiza Martins Nascentes Melo, Feyza Cansiz, Alpaslan Tasdogan

引用次数: 0

Abstract

Aldolase A is one of the glycolytic enzymes that regulate cancer cell proliferation. A new study identifies aldolase A as a critical node that, when inhibited in cancer cells, turns glycolysis into an ATP-consuming process. Targeting aldolase A to induce imbalanced glycolysis could overcome the intrinsic metabolic plasticity of cancer cells.

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醛缩酶A：糖酵解的中间人

醛缩酶A是调节癌细胞增殖的糖酵解酶之一。一项新的研究发现醛缩酶A是一个关键节点，当在癌细胞中被抑制时，它会将糖酵解转化为一个消耗atp的过程。靶向醛缩酶A诱导不平衡糖酵解可以克服癌细胞固有的代谢可塑性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature metabolism ENDOCRINOLOGY & METABOLISM-

CiteScore

27.50

自引率

2.40%

发文量

170

期刊介绍： Nature Metabolism is a peer-reviewed scientific journal that covers a broad range of topics in metabolism research. It aims to advance the understanding of metabolic and homeostatic processes at a cellular and physiological level. The journal publishes research from various fields, including fundamental cell biology, basic biomedical and translational research, and integrative physiology. It focuses on how cellular metabolism affects cellular function, the physiology and homeostasis of organs and tissues, and the regulation of organismal energy homeostasis. It also investigates the molecular pathophysiology of metabolic diseases such as diabetes and obesity, as well as their treatment. Nature Metabolism follows the standards of other Nature-branded journals, with a dedicated team of professional editors, rigorous peer-review process, high standards of copy-editing and production, swift publication, and editorial independence. The journal has a high impact factor, has a certain influence in the international area, and is deeply concerned and cited by the majority of scholars.