The KNL-1/Knl1 outer kinetochore protein caught regulating F-actin.

IF 7.4 1区生物学 Q1 CELL BIOLOGY

Journal of Cell Biology Pub Date : 2025-01-16 DOI:10.1083/jcb.202412191

Hannes E Bülow

引用次数: 0

Abstract

Kinetochores are multiprotein complexes that link chromosomes to microtubules and are essential for chromosome segregation during cell divisions. In this issue, Alves Domingos et al. (https://doi.org/10.1083/jcb.202311147) show that the conserved KNL-1/Knl1 protein of the Knl1/Mis12/Ndc80 (KMN) outer kinetochore complex postmitotically regulates F-actin to shape somatosensory dendrites.

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KNL-1/Knl1外着丝点蛋白调控f -肌动蛋白。

着丝点是连接染色体和微管的多蛋白复合物，在细胞分裂过程中对染色体分离至关重要。在本期中，Alves Domingos等人（https://doi.org/10.1083/jcb.202311147）表明，Knl1/Mis12/Ndc80 （KMN）外着丝点复合体的保守的KNL-1/Knl1蛋白在有丝分裂后调节F-actin形成体感觉树突。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Cell Biology 生物-细胞生物学

CiteScore

12.60

自引率

2.60%

发文量

213

审稿时长

1 months

期刊介绍： The Journal of Cell Biology (JCB) is a comprehensive journal dedicated to publishing original discoveries across all realms of cell biology. We invite papers presenting novel cellular or molecular advancements in various domains of basic cell biology, along with applied cell biology research in diverse systems such as immunology, neurobiology, metabolism, virology, developmental biology, and plant biology. We enthusiastically welcome submissions showcasing significant findings of interest to cell biologists, irrespective of the experimental approach.