Programming of synthetic regulatory DNA for cell-type targeting in humans

IF 14.5 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Molecular Cell Pub Date : 2025-01-16 DOI:10.1016/j.molcel.2024.12.019

Leandro N. Ventimiglia, Aleksej Zelezniak

引用次数: 0

Abstract

In a recent study in Nature, Gosai et al.¹ introduce a framework to engineer and validate synthetic DNA regulatory elements showing cell-type-specific activity in human cell lines, closing the distance to the machine-driven design of functional regulatory sequences with therapeutic applications in humans.

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人类细胞类型靶向的合成调控DNA编程

在最近发表于《自然》（Nature）的一项研究中，Gosai 等人1 提出了一个框架，用于设计和验证在人类细胞系中显示出细胞类型特异性活性的合成 DNA 调控元件，从而拉近了机器驱动的功能性调控序列设计与人类治疗应用之间的距离。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molecular Cell 生物-生化与分子生物学

CiteScore

26.00

自引率

3.80%

发文量

389

审稿时长

1 months

期刊介绍： Molecular Cell is a companion to Cell, the leading journal of biology and the highest-impact journal in the world. Launched in December 1997 and published monthly. Molecular Cell is dedicated to publishing cutting-edge research in molecular biology, focusing on fundamental cellular processes. The journal encompasses a wide range of topics, including DNA replication, recombination, and repair; Chromatin biology and genome organization; Transcription; RNA processing and decay; Non-coding RNA function; Translation; Protein folding, modification, and quality control; Signal transduction pathways; Cell cycle and checkpoints; Cell death; Autophagy; Metabolism.