Serum laminin γ2 monomer as a novel diagnostic and prognostic marker for pancreatic ductal adenocarcinoma.

BJC reports Pub Date : 2025-01-14 DOI:10.1038/s44276-024-00116-z

Takeshi Terashima, Kouki Nio, Naohiko Koshikawa, Makoto Ueno, Tadashi Toyama, Masaki Miyazawa, Tomoyuki Hayashi, Akihiro Seki, Hidetoshi Nakagawa, Noriho Iida, Shinya Yamada, Hajime Takatori, Tetsuro Shimakami, Toru Yoshimura, Eisaku Yoshida, Masatoshi Nakagawa, Motoharu Seiki, Taro Yamashita

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Abstract

Background: The identification of effective diagnostic and prognostic biomarkers is critical to improving the outcomes of patients with pancreatic ductal adenocarcinoma (PDAC). We explored the potential of serum levels of laminin γ2 monomer (LG2m) as a biomarker in PDAC.

Methods: This study included two cohorts. Cohort 1 included 142 PDAC patients, 55 patients with intraductal papillary mucinous neoplasm (IPMN), and 46 healthy individuals. Cohort 2 included 518 PDAC patients. The medical records of patients were reviewed. Cut-off levels for LG2m were determined by receiver operating characteristic analysis.

Results: In Cohort 1, serum LG2m levels were significantly higher in PDAC patients compared with healthy individuals (P < 0.001) and IPMN patients (P < 0.001). Comparing PDAC patients and health individuals, the optimal cut-off level of LG2m was 9.55 pg/mL and the sensitivity, specificity, and area under the curve were 0.89, 0.87, and 0.88, respectively. High sensitivity of LG2m in PDAC patients were confirmed in Cohort 2. The sensitivity and specificity of LG2m was higher than that of CEA and CA19-9. In patients treated with resection or chemotherapy, high serum LG2m level indicated a significantly shorter survival (P = 0.042 and P < 0.001, respectively).

Conclusions: LG2m may be a useful diagnostic and prognostic marker for PDAC.

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血清层粘连蛋白γ - 2单体作为胰腺导管腺癌新的诊断和预后指标。

背景：确定有效的诊断和预后生物标志物对改善胰腺导管腺癌（PDAC）患者的预后至关重要。我们探索了层粘连蛋白γ - 2单体（LG2m）的血清水平作为PDAC的生物标志物的潜力。方法：本研究包括两个队列。队列1包括142例PDAC患者，55例导管内乳头状粘液瘤（IPMN）患者和46例健康个体。队列2包括518例PDAC患者。对病人的医疗记录进行了审查。通过受试者工作特征分析确定LG2m的截止水平。结果：在队列1中，PDAC患者血清LG2m水平明显高于健康个体(P结论：LG2m可能是PDAC的有用诊断和预后指标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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BJC reports

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