Marriage is associated with decreased lesion volumes and less brain atrophy in people with multiple sclerosis.

IF 4.8 2区医学 Q1 CLINICAL NEUROLOGY

Journal of Neurology Pub Date : 2025-01-15 DOI:10.1007/s00415-024-12823-1

Alexandra Balshi, John Dempsey, Sachin Kumbar, Grace Leunberger, Ursela Baber, Jacob A Sloane

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引用次数: 0

Abstract

Background: Married or long-term partnered patients with chronic diseases generally have better outcomes than unmarried patients, likely due to the potential for multifaceted support. However, the impact of marital status on multiple sclerosis (MS) radiographic disease burden is currently unknown.

Objective: To compare total white matter hyperintensity lesion volumes, periventricular lesion volumes, and whole brain and grey matter volumes in married and unmarried people with MS (PwMS).

Methods: We utilized multivariable linear regression to assess for differences in brain atrophy and lesion volumes between these two groups controlling for sex, MS disease duration in years, hypertension, history of smoking, alcohol consumption, history of depression and/or anxiety, and medication possession ratio (MPR).

Results: Married PwMS had significantly lower total lesion volumes (β = - 6.3, 95% CI - 12.1 to - 0.5, p = 0.033), lower PV lesion volumes (β = - 6.1, 95% CI - 11.7 to - 0.6, p = 0.030), higher normalized whole brain volumes (β = 38.3, 95% CI 6.0 to 70.7, p = 0.021), and higher normalized grey matter volumes (β = 20.9, 95% CI - 0.7 to 42.6, p = 0.058) than unmarried PwMS.

Conclusion: Being married may be associated with improved MS outcomes as evidenced by decreased radiographic MS disease burden.

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婚姻与多发性硬化症患者的病变体积减少和脑萎缩减少有关。

背景：已婚或有长期伴侣的慢性疾病患者通常比未婚患者有更好的预后，可能是由于潜在的多方面支持。然而，婚姻状况对多发性硬化症（MS）影像学疾病负担的影响目前尚不清楚。目的：比较已婚和未婚多发性硬化症（PwMS）患者脑白质高强度病变总体积、脑室周围病变体积、全脑和灰质体积。方法：采用多变量线性回归评估两组脑萎缩和病变体积的差异，控制性别、MS病程年数、高血压、吸烟、饮酒史、抑郁和/或焦虑史以及药物占有比（MPR）。结果：与未婚PwMS相比，已婚PwMS的总病变体积（β = - 6.3, 95% CI - 12.1 ~ - 0.5, p = 0.033）、PV病变体积（β = - 6.1, 95% CI - 11.7 ~ - 0.6, p = 0.030）、全脑归一化体积（β = 38.3, 95% CI - 6.0 ~ 70.7, p = 0.021）和灰质归一化体积（β = 20.9, 95% CI - 0.7 ~ 42.6, p = 0.058）显著降低。结论：结婚可能与MS预后的改善有关，影像学上MS疾病负担的减轻证明了这一点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Neurology 医学-临床神经学

CiteScore

10.00

自引率

5.00%

发文量

558

审稿时长

1 months

期刊介绍： The Journal of Neurology is an international peer-reviewed journal which provides a source for publishing original communications and reviews on clinical neurology covering the whole field. In addition, Letters to the Editors serve as a forum for clinical cases and the exchange of ideas which highlight important new findings. A section on Neurological progress serves to summarise the major findings in certain fields of neurology. Commentaries on new developments in clinical neuroscience, which may be commissioned or submitted, are published as editorials. Every neurologist interested in the current diagnosis and treatment of neurological disorders needs access to the information contained in this valuable journal.