Glycobiology of psoriasis: A review

IF 7.9 1区医学 Q1 IMMUNOLOGY

Journal of autoimmunity Pub Date : 2025-02-01 DOI:10.1016/j.jaut.2025.103361

Yinuo Yang , Xin Zhou , Wenhui Wang , Hui Dai

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Abstract

Psoriasis is a chronic inflammatory skin disease with etiologies related to genetics, immunity, and the environment. It is characterized by excessive proliferation of keratinocytes and infiltration of inflammatory immune cells. Glycosylation is a post-translational modification of proteins that plays important roles in cell adhesion, signal transduction, and immune cell activation. Abnormal glycosylation is associated with inflammation, tumors, autoimmunity, and several diseases. Glycan profiles and glycosylation-related enzymes are altered in patients with psoriasis. Specific glycan structures, such as glycosaminoglycans and gangliosides, inhibit the development of psoriasis through various pathways. Lectins are glycan-binding proteins that are widely involved in the pathogenesis of psoriasis. The differential serum, epidermal, and dermal expression of galectins in patients with psoriasis distinguishes psoriasis from other nonspecific psoriasis-like dermatitis. This article summarizes relevant literature on psoriasis-related glycans to help clarify the potential molecular mechanisms of psoriasis and identify novel biomarkers and targets for the treatment of psoriasis.

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银屑病的糖生物学研究进展。

牛皮癣是一种慢性炎症性皮肤病，其病因与遗传、免疫和环境有关。它的特点是角化细胞过度增殖和炎症免疫细胞浸润。糖基化是蛋白质的翻译后修饰，在细胞粘附、信号转导和免疫细胞活化中起重要作用。异常糖基化与炎症、肿瘤、自身免疫和几种疾病有关。银屑病患者的多糖谱和糖基化相关酶发生改变。特定的聚糖结构，如糖胺聚糖和神经节苷，通过多种途径抑制银屑病的发展。凝集素是一种聚糖结合蛋白，广泛参与牛皮癣的发病机制。银屑病患者血清、表皮和真皮中凝集素表达的差异将银屑病与其他非特异性银屑病样皮炎区分开来。本文综述了银屑病相关聚糖的相关文献，旨在阐明银屑病的潜在分子机制，寻找新的生物标志物和治疗银屑病的靶点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of autoimmunity 医学-免疫学

CiteScore

27.90

自引率

1.60%

发文量

117

审稿时长

17 days

期刊介绍： The Journal of Autoimmunity serves as the primary publication for research on various facets of autoimmunity. These include topics such as the mechanism of self-recognition, regulation of autoimmune responses, experimental autoimmune diseases, diagnostic tests for autoantibodies, as well as the epidemiology, pathophysiology, and treatment of autoimmune diseases. While the journal covers a wide range of subjects, it emphasizes papers exploring the genetic, molecular biology, and cellular aspects of the field. The Journal of Translational Autoimmunity, on the other hand, is a subsidiary journal of the Journal of Autoimmunity. It focuses specifically on translating scientific discoveries in autoimmunity into clinical applications and practical solutions. By highlighting research that bridges the gap between basic science and clinical practice, the Journal of Translational Autoimmunity aims to advance the understanding and treatment of autoimmune diseases.