Biometallic ions and derivatives: a new direction for cancer immunotherapy

IF 27.7 1区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Molecular Cancer Pub Date : 2025-01-15 DOI:10.1186/s12943-025-02225-w

Lin Zhao, Yajun Gui, Jing Cai, Xiangying Deng

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Abstract

Biometallic ions play a crucial role in regulating the immune system. In recent years, cancer immunotherapy has become a breakthrough in cancer treatment, achieving good efficacy in a wide range of cancers with its specificity and durability advantages. However, existing therapies still face challenges, such as immune tolerance and immune escape. Biometallic ions (e.g. zinc, copper, magnesium, manganese, etc.) can assist in enhancing the efficacy of immunotherapy through the activation of immune cells, enhancement of tumor antigen presentation, and improvement of the tumor microenvironment. In addition, biometallic ions and derivatives can directly inhibit tumor cell progression and offer the possibility of effectively overcoming the limitations of current cancer immunotherapy by promoting immune responses and reducing immunosuppressive signals. This review explores the role and potential application prospects of biometallic ions in cancer immunotherapy, providing new ideas for future clinical application of metal ions as part of cancer immunotherapy and helping to guide the development of more effective and safe therapeutic regimens.

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生物金属离子及其衍生物：癌症免疫治疗的新方向

生物金属离子在调节免疫系统中起着至关重要的作用。近年来，癌症免疫治疗已成为癌症治疗的突破口，以其特异性和持久性的优势，在广泛的癌症中取得了良好的疗效。然而，现有的治疗方法仍然面临着免疫耐受和免疫逃逸等挑战。生物金属离子（如锌、铜、镁、锰等）可以通过激活免疫细胞、增强肿瘤抗原呈递和改善肿瘤微环境来帮助提高免疫治疗的疗效。此外，生物金属离子及其衍生物可以直接抑制肿瘤细胞的进展，并通过促进免疫反应和减少免疫抑制信号，有效克服当前癌症免疫治疗的局限性。本文综述了生物金属离子在肿瘤免疫治疗中的作用及潜在应用前景，为金属离子在肿瘤免疫治疗中的临床应用提供了新的思路，有助于指导开发更有效、更安全的治疗方案。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molecular Cancer 医学-生化与分子生物学

CiteScore

54.90

自引率

2.70%

发文量

224

审稿时长

2 months

期刊介绍： Molecular Cancer is a platform that encourages the exchange of ideas and discoveries in the field of cancer research, particularly focusing on the molecular aspects. Our goal is to facilitate discussions and provide insights into various areas of cancer and related biomedical science. We welcome articles from basic, translational, and clinical research that contribute to the advancement of understanding, prevention, diagnosis, and treatment of cancer. The scope of topics covered in Molecular Cancer is diverse and inclusive. These include, but are not limited to, cell and tumor biology, angiogenesis, utilizing animal models, understanding metastasis, exploring cancer antigens and the immune response, investigating cellular signaling and molecular biology, examining epidemiology, genetic and molecular profiling of cancer, identifying molecular targets, studying cancer stem cells, exploring DNA damage and repair mechanisms, analyzing cell cycle regulation, investigating apoptosis, exploring molecular virology, and evaluating vaccine and antibody-based cancer therapies. Molecular Cancer serves as an important platform for sharing exciting discoveries in cancer-related research. It offers an unparalleled opportunity to communicate information to both specialists and the general public. The online presence of Molecular Cancer enables immediate publication of accepted articles and facilitates the presentation of large datasets and supplementary information. This ensures that new research is efficiently and rapidly disseminated to the scientific community.