Primary breast Burkitt lymphoma with lactic acidosis in a child: a case report.

The Turkish journal of pediatrics Pub Date : 2024-12-30 DOI:10.24953/turkjpediatr.2024.4681

Eren Müngen, Nilgün Kurucu, Tezer Kutluk, H Nursun Özcan, Selman Kesici, Diclehan Orhan

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Abstract

Background: Primary breast lymphoma is extremely rare and constitutes approximately 1% of all non-Hodgkin's lymphomas (NHL). Only 1-5% of them are Burkitt type. We present a case of childhood primary breast Burkitt lymphoma (BL).

Case presentation: A 16-year-old female patient was referred to our hospital for bilateral breast swelling and respiratory distress. She had lactic acidosis. Despite aggressive dialysis support, lactic acid levels started to decrease only after the combination chemotherapy treatment was started and returned to normal. Histopathological examination of the biopsy was consistent with the diagnosis of BL. The case was classified as stage 4 disease. EICNHL Mature B NHL protocol, Group C3 chemotherapy was given and a very good partial response was achieved. However, the patient died due to fungal septicemia.

Conclusion: Type B lactic acidosis in aggressive malignancies indicates a poor prognosis. In such cases, as in our case, lactic acidosis improves only with appropriate and sufficient chemotherapy, and its improvement is an important indicator that the case is responsive to treatment.

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儿童原发性乳腺伯基特淋巴瘤伴乳酸性酸中毒1例。

背景：原发性乳腺淋巴瘤极为罕见，约占所有非霍奇金淋巴瘤（NHL）的1%。其中只有1-5%是伯基特型。我们报告一例儿童原发性乳腺伯基特淋巴瘤（BL）。病例介绍：一位16岁的女性患者因双侧乳房肿胀和呼吸窘迫而转诊至我院。她有乳酸酸中毒。尽管有积极的透析支持，乳酸水平只有在联合化疗开始后才开始下降并恢复正常。活检的组织病理学检查与BL的诊断一致，该病例被归类为4期疾病。EICNHL成熟B型NHL方案，给予C3组化疗，取得了很好的部分缓解。然而，患者死于真菌败血症。结论：侵袭性恶性肿瘤B型乳酸酸中毒预后较差。在这种情况下，如我们的病例，乳酸酸中毒只有通过适当和充分的化疗才能改善，其改善是该病例对治疗有反应的重要指标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The Turkish journal of pediatrics

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