Ketamine Infusion for Complex Regional Pain Syndrome Treatment: A Narrative Review.

IF 3.2 2区医学 Q2 CLINICAL NEUROLOGY

Current Pain and Headache Reports Pub Date : 2025-01-14 DOI:10.1007/s11916-025-01360-9

Alan D Kaye, Brynne E Tynes, Coplen D Johnson, Bryan C Strong, Brennan M Abbott, Jelena Vučenović, Omar Viswanath, Charles J Fox, Shahab Ahmadzadeh, Sam N Amarasinghe, Saurabh Kataria, Sahar Shekoohi

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引用次数: 0

Abstract

Purpose of review: Complex Regional Pain Syndrome (CRPS) is a neuropathic pain disorder characterized by pain disproportionate to the inciting event that is constant for an extended duration. Numerous treatment options for this condition have been explored with unsatisfactory results in many cases. Ketamine, an N-methyl-D-aspartate (NMDA) receptor antagonist typically used as an anesthetic and analgesic, presents a promising potential treatment for CRPS in patients who fail to respond to traditional therapies.

Recent findings: Numerous studies report significant improvement in the degree of pain, mobility of extremities, and other parameters after ketamine infusion in patients with CRPS. Although adverse effects were not reported often, some subjects experienced nausea, vomiting, headache or psychotropic or psychomimetic symptoms which could be mitigated with cessation of the drug. Although more research is needed to determine optimal dosing and duration, ketamine seems to be a safe and effective treatment for refractory cases of CRPS.

Conclusion: The present investigation summarizes existing knowledge and research surrounding ketamine infusions for CRPS to provide a well-rounded depiction of advantages and disadvantages for physicians who may be considering it for patients with this challenging and complex condition.

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氯胺酮输注治疗复杂局部疼痛综合征：叙述性综述。

综述目的：复杂区域性疼痛综合征（CRPS）是一种神经性疼痛障碍，其特征是疼痛与刺激事件不成比例，持续时间长。对于这种情况，已经探索了许多治疗方案，但在许多情况下结果并不令人满意。氯胺酮是一种n -甲基- d -天冬氨酸（NMDA）受体拮抗剂，通常用作麻醉剂和镇痛药，对于传统治疗无效的CRPS患者来说，氯胺酮是一种有希望的潜在治疗方法。最近的发现：大量研究报告氯胺酮输注后，CRPS患者的疼痛程度、四肢活动能力和其他参数显著改善。虽然不良反应不常被报道，但一些受试者出现恶心、呕吐、头痛或精神或拟精神症状，这些症状可在停药后减轻。虽然需要更多的研究来确定最佳剂量和持续时间，氯胺酮似乎是一种安全有效的治疗难治性CRPS病例。结论：本研究总结了氯胺酮输注治疗CRPS的现有知识和研究，为可能考虑为这种具有挑战性和复杂性的患者输注氯胺酮的医生提供了一个全面的利弊描述。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Pain and Headache Reports CLINICAL NEUROLOGY-

CiteScore

6.10

自引率

2.70%

发文量

审稿时长

6-12 weeks

期刊介绍： This journal aims to review the most important, recently published clinical findings regarding the diagnosis, treatment, and management of pain and headache. By providing clear, insightful, balanced contributions by international experts, the journal intends to serve all those involved in the care and prevention of pain and headache. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as anesthetic techniques in pain management, cluster headache, neuropathic pain, and migraine. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also provided.