Changes in Functional Activity of Platelets under the Influence of Submicron Particles Based on Mesoporous Silica and pH-Sensitive Polymers.

IF 0.9 4区医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL

Bulletin of Experimental Biology and Medicine Pub Date : 2024-12-01 Epub Date: 2025-01-07 DOI:10.1007/s10517-025-06308-y

A N Ivanov, A O Kuznetsov, D D Loiko, Yu N Vlasicheva, E V Lengert, A V Ermakov

引用次数: 0

Abstract

In vitro and in vivo effects of mesoporous silica nanoparticles (MSN) on the functional activity of platelets were studied in experiments on white rats. MSN particles, neither uncoated nor coated with calcium alginate, induced spontaneous platelet aggregation when added to platelet-rich plasma, but significantly enhanced ADP-induced platelet aggregation. Subcutaneous administration of uncoated and calcium alginate-coated MSN resulted in increased maximum size and rate of platelet aggregate formation 1 day post-injection. In contrast, cellulose-coated MSN had no significant effect on platelet function in vitro or in vivo, suggesting their potential as carriers for targeted drug delivery.

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基于介孔二氧化硅和ph敏感聚合物的亚微米颗粒影响下血小板功能活性的变化。

研究了介孔二氧化硅纳米颗粒（MSN）对大鼠血小板功能活性的体内外影响。无论未包被海藻酸钙还是包被海藻酸钙的MSN颗粒加入富血小板血浆中，都能诱导血小板自发聚集，但显著增强adp诱导的血小板聚集。皮下注射未包被和海藻酸钙包被的MSN，在注射后1天血小板聚集形成的最大尺寸和速率增加。相比之下，纤维素包被的MSN在体外和体内对血小板功能没有显著影响，这表明它们作为靶向药物递送载体的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Bulletin of Experimental Biology and Medicine 医学-医学：研究与实验

CiteScore

1.50

自引率

14.30%

发文量

265

审稿时长

2 months

期刊介绍： Bulletin of Experimental Biology and Medicine presents original peer reviewed research papers and brief reports on priority new research results in physiology, biochemistry, biophysics, pharmacology, immunology, microbiology, genetics, oncology, etc. Novel trends in science are covered in new sections of the journal - Biogerontology and Human Ecology - that first appeared in 2005. World scientific interest in stem cells prompted inclusion into Bulletin of Experimental Biology and Medicine a quarterly scientific journal Cell Technologies in Biology and Medicine (a new Russian Academy of Medical Sciences publication since 2005). It publishes only original papers from the leading research institutions on molecular biology of stem and progenitor cells, stem cell as the basis of gene therapy, molecular language of cell-to-cell communication, cytokines, chemokines, growth and other factors, pilot projects on clinical use of stem and progenitor cells. The Russian Volume Year is published in English from April.