High-throughput Experimentation Enables the Development of a Nickel-catalyzed Cyanation Platform for (Hetero)aryl Halides.

IF 3.9 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Chemistry - A European Journal Pub Date : 2025-01-14 DOI:10.1002/chem.202403795

Vincent Porte, Philipp Kollmus, Eloisa Serrano, Marco Santagostino

引用次数: 0

Abstract

A novel screening platform for the nickel-catalyzed cyanation of (hetero)aryl halides relying on the use of air-stable Ni(COD)DQ at low loading is reported. Through high-throughput experimentation (HTE), various ligand and solvent combinations are systematically explored, allowing the fast identification of suitable conditions. This standardized workflow serves as an excellent starting point for selecting other competent nickel precatalysts and for further optimization of reluctant substrates. The transformation exhibits broad functional group tolerance and can be readily scaled up to gram-scale.

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高通量实验使镍催化（杂）芳基卤化物氰化平台的发展。

报道了一种基于空气稳定Ni(COD)DQ的低负荷镍催化杂环芳烃卤化物氰化反应的新型筛选平台。通过高通量实验（HTE），系统地探索各种配体和溶剂组合，从而快速确定合适的条件。这个标准化的工作流程为选择其他称职的镍预催化剂和进一步优化不情愿的底物提供了一个很好的起点。转化表现出广泛的官能团耐受性，可以很容易地扩大到克规模。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Chemistry - A European Journal 化学-化学综合

CiteScore

7.90

自引率

4.70%

发文量

1808

审稿时长

1.8 months

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