Nasal food challenge with hen's egg white allergen.

IF 2.6 4区医学 Q2 ALLERGY

Allergy Asthma and Clinical Immunology Pub Date : 2025-01-12 DOI:10.1186/s13223-024-00945-0

Edyta Krzych-Fałta, Andrzej Namysłowski, Sławomir Białek, Monika E Czerwińska, Konrad Furmańczyk, Aleksandra Tylewicz, Adam Sybilski, Bolesław Samoliński, Oksana Wojas

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引用次数: 0

Abstract

Background: Nasal allergen provocation tests are an important part of the diagnostics of allergic diseases triggered by environmental factors. Recently, increased attention has been paid to the potential use of this method in the diagnosis of food allergy. The objective of the study was to evaluate the usefulness of the nasal allergen provocation test in a group of subjects allergic to hen's egg white allergens.

Methods: The material consisted of a group of 57 subjects (32 subjects with hen's egg white allergy and 25 healthy controls). The method consisted in a nasal allergen provocation test carried out with the use of hen's egg white allergen and assessed using the visual analog scale and optical rhinometry as well as by determination of sIgE and tryptase levels in nasal lavage fluid.

Results: Subjective nasal symptoms and objective evaluations following the application of 100 µg of hen's egg white allergen revealed a moderately positive nasal mucosal response in optical rhinometry tests (ΔE = 0.34 OD).

Conclusions: Nasal food challenge with hen's egg white allergen is a good diagnostic alternative in the group of food allergy patients. Due to the insufficient number of studies carried out so far, further attempts at standardization of the method are required.

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蛋清过敏原对鼻腔食物的影响。

背景：鼻致应原激发试验是环境因素诱发的变应性疾病诊断的重要组成部分。近年来，人们越来越关注这种方法在食物过敏诊断中的潜在应用。本研究的目的是评估鼻腔过敏原激发试验在一组对蛋清过敏原过敏的受试者中的有效性。方法：实验对象57人，其中蛋清过敏者32人，健康对照25人。该方法采用蛋清过敏原进行鼻腔过敏原激发试验，采用视觉模拟量表和光学鼻测量法以及测定鼻灌洗液中sIgE和胰蛋白酶水平进行评估。结果：应用100µg蛋清过敏原后的主观鼻症状和客观评价在光学鼻测量测试中显示中度阳性鼻黏膜反应（ΔE = 0.34 OD）。结论：蛋清过敏原鼻腔刺激是一种较好的食物过敏诊断方法。由于迄今为止进行的研究数量不足，需要进一步尝试将该方法标准化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Allergy Asthma and Clinical Immunology ALLERGY-IMMUNOLOGY

CiteScore

4.30

自引率

3.70%

发文量

审稿时长

12 weeks

期刊介绍： Allergy, Asthma & Clinical Immunology (AACI), the official journal of the Canadian Society of Allergy and Clinical Immunology (CSACI), is an open access journal that encompasses all aspects of diagnosis, epidemiology, prevention and treatment of allergic and immunologic disease. By offering a high-visibility forum for new insights and discussions, AACI provides a platform for the dissemination of allergy and clinical immunology research and reviews amongst allergists, pulmonologists, immunologists and other physicians, healthcare workers, medical students and the public worldwide. AACI reports on basic research and clinically applied studies in the following areas and other related topics: asthma and occupational lung disease, rhinoconjunctivitis and rhinosinusitis, drug hypersensitivity, allergic skin diseases, urticaria and angioedema, venom hypersensitivity, anaphylaxis and food allergy, immunotherapy, immune modulators and biologics, immune deficiency and autoimmunity, T cell and B cell functions, regulatory T cells, natural killer cells, mast cell and eosinophil functions, complement abnormalities.