Modulation mode of amygdala morphology and cognitive function under acute sleep deprivation in healthy male

IF 3.8 2区医学 Q1 CLINICAL NEUROLOGY

Sleep medicine Pub Date : 2025-01-09 DOI:10.1016/j.sleep.2025.01.008

Haoyuan Zhang , Lili Xu , Xiaohan Yi , Xiangzi Zhang

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引用次数: 0

Abstract

The amygdala plays a crucial role in various behavioral functions and psychiatric conditions, with its morphology showing alterations in sleep disorders. While the impact of chronic sleep disorders on amygdala morphology has been studied, the effects of acute sleep deprivation (ASD) remain largely unexplored. The present study aimed to investigate the modulation between amygdala sub-region volumes and spatial working memory (SWM) performance under ASD conditions. Twenty-eight healthy male participants underwent MRI scanning and performed SWM tasks before and after 24 h of ASD. Amygdala sub-region volumes were segmented into nine sub-regions, and Granger causality analysis was employed to examine the relationship between amygdala morphology and SWM performance. Results revealed significant decreases in SWM accuracy and increases in reaction time following ASD. Localized changes in amygdala sub-regions were observed, with increased left cortico-amygdaloid transition area (CAT) volume and decreased right paralaminar nucleus (PL) volume. Granger causality analysis uncovered a bidirectional modulation between centromedial and cortical-like nuclei, and a progressive involvement of amygdala sub-regions in modulating SWM performance as task difficulty increased. These findings demonstrate a complex interplay between sleep, amygdala morphology, and cognitive function, suggesting that the amygdala plays a crucial role in modulating cognitive performance under ASD conditions. The differential involvement of amygdala sub-regions across varying cognitive loads indicates a flexible and adaptive system attempting to maintain performance in the face of sleep loss.

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急性睡眠剥夺下健康男性杏仁核形态和认知功能的调节模式。

杏仁核在各种行为功能和精神疾病中起着至关重要的作用，其形态在睡眠障碍中表现出改变。虽然慢性睡眠障碍对杏仁核形态的影响已经被研究过，但急性睡眠剥夺（ASD）的影响在很大程度上仍未被探索。本研究旨在探讨ASD条件下杏仁核亚区体积与空间工作记忆（SWM）表现之间的调节关系。28名健康男性参与者在ASD发生前和24小时后分别接受了MRI扫描和SWM任务。将杏仁核亚区体积划分为9个亚区，并采用格兰杰因果分析来检验杏仁核形态与SWM表现之间的关系。结果显示，ASD后SWM准确性显著降低，反应时间显著增加。杏仁核亚区局部改变，左侧皮质-杏仁核过渡区（CAT）体积增加，右侧线旁核（PL）体积减少。格兰杰因果分析揭示了中央核和皮质样核之间的双向调节，并且随着任务难度的增加，杏仁核亚区逐渐参与调节SWM的表现。这些发现表明睡眠、杏仁核形态和认知功能之间存在复杂的相互作用，表明杏仁核在调节ASD患者的认知表现中起着至关重要的作用。杏仁核子区域在不同认知负荷下的不同参与表明，面对睡眠不足，一个灵活的适应性系统试图保持表现。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Sleep medicine 医学-临床神经学

CiteScore

8.40

自引率

6.20%

发文量

1060

审稿时长

49 days

期刊介绍： Sleep Medicine aims to be a journal no one involved in clinical sleep medicine can do without. A journal primarily focussing on the human aspects of sleep, integrating the various disciplines that are involved in sleep medicine: neurology, clinical neurophysiology, internal medicine (particularly pulmonology and cardiology), psychology, psychiatry, sleep technology, pediatrics, neurosurgery, otorhinolaryngology, and dentistry. The journal publishes the following types of articles: Reviews (also intended as a way to bridge the gap between basic sleep research and clinical relevance); Original Research Articles; Full-length articles; Brief communications; Controversies; Case reports; Letters to the Editor; Journal search and commentaries; Book reviews; Meeting announcements; Listing of relevant organisations plus web sites.