Psychotic-Spectrum Disorders With Comorbid Anxiety are Predisposing Factors for Parkinson's Disease in a Case-Control Study.

Q2 Social Sciences

The Permanente journal Pub Date : 2025-01-12 DOI:10.7812/TPP/24.131

Anna Shvartsur, Kelli Peterman, Nirmala D Ramalingam, Roy Eyal, Suketu Khandhar, Michel Medina, Matthew E Hirschtritt

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引用次数: 0

Abstract

Background: Multiple studies have demonstrated associations between psychiatric conditions and Parkinson's disease (PD) development; fewer have examined psychotic-spectrum disorders and PD development.

Objective: The objective was to assess the prevalence of psychotic-spectrum disorders with and without depression and anxiety preceding a PD diagnosis.

Methods: In this retrospective, case-control study of adults > 60 years of age, cases were identified by PD diagnosis and controls were identified in a 3:1 ratio by ambulatory encounter from 2015 to 2020. Psychiatric conditions were identified by diagnosis code up to 5 years prior to the index date. Conditional logistic regression was conducted to assess associations.

Results: Among 13,998 patients, the odds of PD were 76% (95% confidence interval = 1.39-2.22) higher among those with psychotic-spectrum diagnoses. An additional anxiety diagnosis was associated with 166% (95% confidence interval = 1.35-5.25) higher odds of PD.

Conclusions: Awareness of psychiatric conditions, including psychotic-spectrum disorders with comorbid anxiety, can stratify individuals at higher risk of developing PD.

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在一项病例对照研究中，伴有焦虑的精神障碍是帕金森病的诱发因素。

背景：多项研究表明精神疾病与帕金森病（PD）发展之间存在关联；很少有人检查过精神谱系障碍和PD的发展。目的：目的是评估PD诊断前伴有和不伴有抑郁和焦虑的精神谱系障碍的患病率。方法：2015年至2020年，对60岁~ 60岁的成年人进行回顾性病例对照研究，通过门诊就诊确诊PD病例，对照以3:1的比例确诊。在索引日期前5年通过诊断代码确定精神疾病。采用条件逻辑回归来评估相关性。结果：在13998例患者中，有精神谱系诊断的患者患PD的几率高出76%（95%置信区间= 1.39-2.22）。额外的焦虑诊断与166%（95%可信区间= 1.35-5.25）的PD风险增加相关。结论：意识到精神疾病，包括伴有共病焦虑的精神谱系障碍，可以对患PD的高风险个体进行分层。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

The Permanente journal Medicine-Medicine (all)

CiteScore

2.20

自引率

0.00%

发文量