Protective roles of herbal teas against the toxicity of Bisphenol A on morphometry of uterus and improving murine reproductive health (incomplete title and amended by the EIC).

Abstract

The purpose of the current study was to investigate the potential ameliorating murine reproductive effects of herbal tea extracts against bisphenol A-induced (BPA) cytotoxicity. A comparative study was applied among red, green and blue teas in mice groups. Samples were coded as RTE, GTE and BTE groups, respectively. Several evaluations of murine reproductive were detected, such as diameters of uterine layers, pregnancy percentage, uterine, and offspring weights. The levels of malondialdehyde (MDA), oxytocin and cortisol were detected in plasma. The pregnancy percentage in the BTE + BPA group was 100% in the negative control group. The uterine weights of the mice groups with herbal teas ranged from 4.12g to 4.77 g. The offspring weights of litter from dams after exposure to BPA and various herbal teas ranged from 17.53g to 25.12 g and from 20.01 g to 28.19 g for females and males, respectively. The BPA toxicity exposure increased MDA levels to reach 19.18ng/ml in the BTE + BPA group as compared with the negative control group of 14.32ng/ml. The exposure to BPA toxins decreased the oxytocin level in the negative control group from 32.55ng/ml to 25.55ng/ml in the RTE + BPA group, while the cortisol levels reached 31.39ng/ml in the GTE + BPA group. The appearance of the luminal epithelial cells and endometrium in the BTE + BPA group was close to normal. It was indicated that herbal teas, particularly blue tea can be able to improve murine reproduction, while the harmful effects of BPA cannot entirely be mitigated.