Comparison of Carbon Dioxide Laser and Surgical Excision for the Treatment of Eyelid Margin Benign Tumors: A Prospective, Randomized, and Single-blind Study.

Abstract

Objectives: This study aims to compare the safety and efficacy between carbon dioxide (CO2) laser excision and surgical excision for the treatment of eyelid margin benign tumors.

Methods: In this single-center, prospective, randomized, and single-blind study, 32 patients diagnosed with eyelid margin benign tumors were enrolled from February 2019 to February 2020 and randomly divided into 2 groups. The sexes, ages, tumor size (length×width), scar, procedure time, physicians' assessment score, patients' satisfaction score, and complications were recorded. Histologic analyses were obtained in all patients.

Results: No significant difference in baseline data (sexes, ages, and tumor size) was found between the 2 groups. The mean scar length at 1-week post-treatment in the CO2 laser excision group was significantly shorter than surgical excision group (0.3±0.1 versus 0.5±0.1 cm, P<0.05), and procedure time in CO2 laser excision group was significantly shorter than surgical excision group (5.8±1.5 versus 26.7±6.4 min, P<0.05). There was no statistically significant difference in the physicians' assessment score and patients' satisfaction score between the 2 groups. During the follow-up period, no severe complications were observed.

Conclusions: Compared with surgical excision, CO2 laser excision was a rapid procedure and associated with favorable cosmetic outcomes.