Biological characterization and clinical significance of cuproptosis-related genes in lung adenocarcinoma.

IF 2.6 3区医学 Q2 RESPIRATORY SYSTEM

BMC Pulmonary Medicine Pub Date : 2025-01-11 DOI:10.1186/s12890-025-03477-4

Meilin Li, Yu Tan, Zhixin Li, Lingfeng Min

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引用次数: 0

Abstract

Background: Lung cancer has high morbidity and mortality rates, which results in a poor prognosis. Cuproptosis is a novel cell death mechanism. The aim of this study was to examine the biological characteristics and clinical significance of genes associated with cuproptosis in lung adenocarcinoma (LUAD), and to understand the molecular mechanisms underlying the occurrence and progression of LUAD.

Methods: We targeted 10 cuproptosis-related genes from previous studies and used the datasets from GEO and TCGA databases to identify differential genes related to cuproptosis; then the data were analyzed by R package, Cytoscape, TISDB, cBioPortal, STRING, CancerSEA, and Disgenet; and finally, the data were detected by immunohistochemistry validation was performed.

Results: CDKN2A and MTF1 were cuproptosis-associated LUAD differential genes and were differentially expressed in immune subtypes. The expression of CDKN2A and MTF1 showed correlation with multiple functional states of LUAD.CDKN2A was negatively correlated with LUAD survival prognosis.

Conclusion: CDKN2A and MTF1 were correlated with the diagnosis of LUAD, and CDKN2A was negatively correlated with the survival and prognosis of LUAD. CDKN2A has the potential to contribute to the early diagnosis and prognosis analysis of LUAD.

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背景：肺癌的发病率和死亡率都很高，因此预后较差。杯突症是一种新型的细胞死亡机制。本研究旨在探讨肺腺癌（LUAD）中杯突相关基因的生物学特征和临床意义，并了解肺腺癌发生和发展的分子机制：我们从以往的研究中锁定了10个杯突症相关基因，并利用GEO和TCGA数据库中的数据集来识别与杯突症相关的差异基因；然后利用R软件包、Cytoscape、TISDB、cBioPortal、STRING、CancerSEA和Disgenet对数据进行分析；最后通过免疫组化验证对数据进行检测：结果：CDKN2A和MTF1是杯突症相关的LUAD差异基因，在免疫亚型中有差异表达。CDKN2A和MTF1的表达与LUAD的多种功能状态相关，CDKN2A与LUAD的生存预后呈负相关：结论：CDKN2A和MTF1与LUAD的诊断相关，CDKN2A与LUAD的生存和预后呈负相关。CDKN2A可能有助于LUAD的早期诊断和预后分析。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

BMC Pulmonary Medicine RESPIRATORY SYSTEM-

CiteScore

4.40

自引率

3.20%

发文量

423

审稿时长

6-12 weeks

期刊介绍： BMC Pulmonary Medicine is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of pulmonary and associated disorders, as well as related molecular genetics, pathophysiology, and epidemiology.