Evaluation of serum levels of irisin, tumor necrosis factor and some biochemical variables in males with prostate cancer in Baghdad City.

IF 1.5 4区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Cellular and molecular biology Pub Date : 2025-01-12 DOI:10.14715/cmb/2024.70.12.21

Hanan Shihab Ahmad, Araf Sabah Abdulwahed, Marwan Abdulrazzaq Kamil

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引用次数: 0

Abstract

Prostate cancer is the most common type after the age of fifty. It affects males and affects the prostate gland, which protects the function of sperm by producing semen. The current study was designed to evaluate prostate cancer infection effects on some biomarkers such as irisin, Tumor necrosis factor-TNF-α, prostate acid phosphates -PAP, Glutathione-GSH, malondialdehyde-MDA, urea, and creatinine. The study was conducted on 50 males infected with prostate cancer and 30 healthy males (control group) who attended the Baghdad Teaching Hospital -Medical City Center/Baghdad, Iraq, from 20/6/2024 to 1/8/2024. The results of the current research showed a significant elevation in (Irisin, TNF-α, PAP, MDA, urea, and creatinine) concentration and a significant decrease in (GSH) concentration in the serum of patients compared to the healthy subjects in the probability of P≤0.05. Irisin and some variables are important physiological biomarkers that can support the diagnosis of prostate cancer.

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巴格达市男性前列腺癌患者血清鸢尾素、肿瘤坏死因子及一些生化指标的评价

前列腺癌是50岁以后最常见的类型。它影响男性并影响前列腺，前列腺通过产生精液来保护精子的功能。本研究旨在评估前列腺癌感染对一些生物标志物的影响，如鸢尾素、肿瘤坏死因子- tnf -α、前列腺酸磷酸-PAP、谷胱甘肽-谷胱甘肽、丙二醛-丙二醛、尿素和肌酐。该研究是在2024年6月20日至2024年8月1日在伊拉克巴格达的巴格达教学医院-医疗城市中心就诊的50名前列腺癌男性和30名健康男性（对照组）中进行的。本研究结果显示，患者血清（鸢尾素、TNF-α、PAP、MDA、尿素、肌酐）浓度较健康者显著升高，（GSH）浓度较健康者显著降低，P≤0.05。鸢尾素和一些变量是支持前列腺癌诊断的重要生理生物标志物。

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来源期刊

Cellular and molecular biology 生物-生化与分子生物学

CiteScore

1.60

自引率

12.50%

发文量

331

期刊介绍： Cellular and Molecular Biology publishes original articles, reviews, short communications, methods, meta-analysis notes, letters to editor and comments in the interdisciplinary science of Cellular and Molecular Biology linking and integrating molecular biology, biophysics, biochemistry, enzymology, physiology and biotechnology in a dynamic cell and tissue biology environment, applied to human, animals, plants tissues as well to microbial and viral cells. The journal Cellular and Molecular Biology is therefore open to intense interdisciplinary exchanges in medical, dental, veterinary, pharmacological, botanical and biological researches for the demonstration of these multiple links.