Characterisation of the HollandPTC R&D proton beamline for physics and radiobiology studies

IF 3.3 3区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
M. Rovituso , C.F. Groenendijk , E. van der Wal , W. van Burik , A. Ibrahimi , H. Rituerto Prieto , J.M.C. Brown , U. Weber , Y. Simeonov , M. Fontana , D. Lathouwers , M. van Vulpen , M. Hoogeman
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引用次数: 0

Abstract

HollandPTC is an independent outpatient center for proton therapy, scientific research, and education. Patients with different types of cancer are treated with Intensity Modulated Proton Therapy (IMPT). Additionally, the HollandPTC R&D consortium conducts scientific research into the added value and improvements of proton therapy. To this end, HollandPTC created clinical and pre-clinical research facilities including a versatile R&D proton beamline for various types of biologically and technologically oriented research. In this work, we present the characterization of the R&D proton beamline of HollandPTC. Its pencil beam mimics the one used for clinical IMPT, with energy ranging from 70 up to 240 MeV, which has been characterized in terms of shape, size, and intensity. For experiments that need a uniform field in depth and lateral directions, a dual ring passive scattering system has been designed, built, and characterized. With this system, field sizes between 2 × 2 cm2 and 20 × 20 cm2 with 98 % uniformity are produced with dose rates ranging from 0.5 Gy/min up to 9 Gy/min. The unique and customized support of the dual ring system allows switching between a pencil beam and a large field in a very simple and fast way, making the HollandPTC R&D proton beam able to support a wide range of different applications.
用于物理和放射生物学研究的HollandPTC R&D质子束线的表征。
HollandPTC是一家独立的质子治疗、科学研究和教育门诊中心。不同类型的癌症患者可接受强度调节质子治疗(IMPT)。此外,HollandPTC研发联盟还对质子治疗的附加值和改进进行科学研究。为此,HollandPTC创建了临床和临床前研究设施,包括用于各种生物和技术导向研究的多功能研发质子束线。在这项工作中,我们介绍了HollandPTC的R&D质子束线的表征。它的铅笔束模拟了临床IMPT使用的光束,能量范围从70到240 MeV,其形状、大小和强度都具有特征。针对在深度和横向上需要均匀场的实验,设计、构建了双环被动散射系统,并对其进行了表征。使用该系统,在0.5 Gy/min至9 Gy/min的剂量率范围内,可以产生2 × 2 cm2至20 × 20 cm2的场大小,均匀性为98%。独特和定制的双环系统支持可以在铅笔束和大场之间以非常简单和快速的方式切换,使HollandPTC研发的质子束能够支持广泛的不同应用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
6.80
自引率
14.70%
发文量
493
审稿时长
78 days
期刊介绍: Physica Medica, European Journal of Medical Physics, publishing with Elsevier from 2007, provides an international forum for research and reviews on the following main topics: Medical Imaging Radiation Therapy Radiation Protection Measuring Systems and Signal Processing Education and training in Medical Physics Professional issues in Medical Physics.
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