Transscleral Pars Plana Choroid Ablation Using the Iridex Laser System Yields Improvements for Surgical Insertion of the Port Delivery Implant in a Minipig Model.

IF 2.3 2区医学 Q2 OPHTHALMOLOGY

Retina-The Journal of Retinal and Vitreous Diseases Pub Date : 2025-01-03 DOI:10.1097/IAE.0000000000004385

Amy Shelton, Melissa Schutten, Reina N Fuji, Ryan Boyd, Victoria Stevenson, Matthew Leahy, Lauren Knupp, Juelline Lieng, Devon Thompson, Tammy Tam, Kevin LaMarche, Giulio Barteselli, Varun Malhotra, Vladimir Bantseev

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引用次数: 0

Abstract

Purpose: To evaluate an alternative surgical approach for Port Delivery System with ranibizumab (PDS) implant and a novel application of Iridex laser system in Gottingen minipig model.

Methods: A total of seventeen male minipigs (Part 1: 9 animals in non-recovery and Part 2: 8 animals observed for 8-days post-surgery Part 2) received PDS implant insertion into each eye. The effect of Iridex 810 nm infrared diode laser with varying energy (power or duration) on transscleral pars plana ablation, surrounding ocular tissue and postsurgical vitreous hemorrhage (VH) was investigated.

Results: The most effective laser parameters for transscleral pars plana ablation in mitigating vitreous hemorrhage with no surrounding tissue damage were continuous wave mode, 1750 mW, 1000 ms, and 16 spots (8 overlapping spots/sweep applied over 2 rows) across a 4 mm segment, posterior to the limbus, delivering a total energy of 28 J. Minimal self-limiting scleral hemorrhage was observed with two of the implants and no VH were observed. µCT imaging was consistent with clinical ophthalmic.

Observations: On microscopic observations, no tissue damage was observed at these laser settings.

Conclusion: This Göttingen minipig model demonstrated a novel application of Iridex laser for transscleral pars plana ablation that streamlines the PDS implantation surgery.

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使用Iridex激光系统经巩膜平面部脉络膜消融改善了迷你猪模型的移植植入手术。

目的：探讨雷尼单抗（PDS）植入体Port给药系统的另一种手术方法和Iridex激光系统在哥廷根微型猪模型中的新应用。方法：选取17只雄性迷你猪（第1部分：未恢复9只，第2部分：术后8 d观察8只）每只眼植入PDS。观察不同能量（功率或持续时间）Iridex 810 nm红外二极管激光对经巩膜平面部消融、眼周组织及术后玻璃体出血的影响。结果：在无周围组织损伤的情况下，经巩膜平面部消融减轻玻璃体出血最有效的激光参数是连续波模式，1750 mW, 1000 ms， 16个点（8个重叠点/扫描超过2行），横跨4 mm段，缘后，提供28j的总能量。微CT影像与临床吻合。观察：在显微镜下观察，在这些激光设置下没有观察到组织损伤。结论：Göttingen迷你猪模型展示了Iridex激光经巩膜平面部消融的新应用，简化了PDS植入手术。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Retina-The Journal of Retinal and Vitreous Diseases 医学-眼科学

CiteScore

5.70

自引率

9.10%

发文量

554

审稿时长

3-6 weeks

期刊介绍： RETINA® focuses exclusively on the growing specialty of vitreoretinal disorders. The Journal provides current information on diagnostic and therapeutic techniques. Its highly specialized and informative, peer-reviewed articles are easily applicable to clinical practice. In addition to regular reports from clinical and basic science investigators, RETINA® publishes special features including periodic review articles on pertinent topics, special articles dealing with surgical and other therapeutic techniques, and abstract cards. Issues are abundantly illustrated in vivid full color. Published 12 times per year, RETINA® is truly a “must have” publication for anyone connected to this field.