Monocular eye-cueing shifts eye balance in amblyopia.

Abstract

Here, we investigate the shift in eye balance in response to monocular cueing in adults with amblyopia. In normally sighted adults, biasing attention toward one eye, by presenting a monocular visual stimulus to it, can shift eye balance toward the stimulated eye, as measured by binocular rivalry. We investigated whether we can modulate eye balance by directing monocular stimulation/attention in adults with clinical binocular deficits associated with amblyopia and larger eye imbalances. In a dual-task paradigm, eight participants continuously reported ongoing rivalry percepts and simultaneously performed a task related to the cueing stimulus. Time series of eye balance dynamics, aligned to cue onset, are averaged across trials and participants. In different time series, we tested the effect of monocular cueing on the amblyopic and fellow eyes (compared to a binocular control condition) and the effect of an active versus passive task. Overall, we found a significant shift in eye balance toward the monocularly cued eye, when both the fellow eye or the amblyopic eye were cued, F(2, 14) = 27.649, p < 0.01, ω2 = 0.590. This was independent of whether, during the binocular rivalry, the cue stimulus was presented to the perceiving eye or the non-perceiving eye. Performing an active task tended to produce a larger eye balance change, but this effect did not reach significance. Our results suggest that the eye imbalance in adults with binocular deficits, such as amblyopia, can be transiently reduced by monocularly directed stimulation, at least through activation of bottom-up attentional processes.