The Role of [¹⁸F]F-FDG PET/CT for Predicting Histology and Prognosis in Patients with Thymic Lesions.

IF 4.1 3区医学 Q1 GENETICS & HEREDITY

Molecular Diagnosis & Therapy Pub Date : 2025-01-07 DOI:10.1007/s40291-024-00767-1

Daniele Antonio Pizzuto, Angelo Castello, Marco Chiappetta, Massimo Castellani, Salvatore Annunziata, Annalisa Campanella, Giuseppe Calabrese, Margherita Cattaneo, Lorenzo Rosso, Giacomo Cusumano, Filippo Lococo, Paolo Mendogni

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引用次数: 0

Abstract

Objectives: To investigate whether 18F-fluorodeoxyglucose positron emission tomography-computed tomography ([¹⁸F]F-FDG PET/CT) metabolic parameters were associated with histology and to assess their prognostic role in patients with thymic lesions.

Patients and methods: In total, 116 patients (49/67 M/F; mean age 59.5 years) who underwent preoperative [¹⁸F]F-FDG PET/CT and thymectomy from 2012 to 2022 were retrospectively analyzed. Associations between histology and metabolic parameters (maximum standardized uptake value (SUVmax), mean standardized uptake value (SUVmean), peak standardized uptake value (SUVpeak), total lesion glycolysis (TLG), metabolic tumor volume (MTV), ratio between target lesion and liver SUVmax (rPET), quotient of SUVpeak in the tumor residual and SUVmean in a 20-cm³ volume of interest (qPET), and tumor-to-mediastinum (T/M) were analyzed. Freedom from recurrence (FFR) was determined and compared using the Kaplan-Meier and the log-rank test. The median follow-up was 38 months (range 14-72 months).

Results: In total, 27 thymic hyperplasia, 41 low-risk thymomas (LRT) (types A, AB, and B1), and 48 high-risk thymomas (HRT) (B2, B3 thymoma, and carcinoma) were included. SUVmax, SUVmean, SUVpeak, rPET, qPET, and T/M were significantly higher in HRT than LRT and hyperplasia (p < 0.001). TLG and MTV were significantly higher in patients with LRT (p < 0.001). Only rPET, qPET, and T/M remained significantly higher in HRT than in LRT subgroups (p = 0.042, p = 0.049, and p = 0.028, respectively). SUVmax, SUVmean, and SUVpeak cutoffs of < 4.3, < 2.87, and 4.03, respectively, significantly distinguished patients with longer FFR (p = 0.009, p = 0.05, and p = 0.05).

Conclusions: Positron emission tomography (PET) metabolic parameters could help to differentiate thymic histotypes. Standardized uptake value (SUV)-based parameters appear promising to predict recurrent disease.

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[18F]F-FDG PET/CT对胸腺病变患者组织学及预后的预测作用

目的：探讨18F-氟脱氧葡萄糖正电子发射断层扫描-计算机断层扫描（[18F]F-FDG PET/CT）代谢参数是否与组织学相关，并评估其在胸腺病变患者中的预后作用。患者和方法：共116例患者(49/67 M/F；回顾性分析2012年至2022年接受术前[18F]F-FDG PET/CT和胸腺切除术的患者，平均年龄59.5岁。分析组织学与代谢参数(最大标准化摄取值（SUVmax）、平均标准化摄取值（SUVmean）、峰值标准化摄取值（SUVpeak）、病变总糖酵解（TLG）、代谢肿瘤体积（MTV）、靶病变与肝脏SUVmax之比（rPET）、肿瘤残余SUVpeak与20 cm3感兴趣体积SUVmean之比（qPET）、肿瘤-纵隔（T/M）之间的关系。使用Kaplan-Meier检验和log-rank检验确定和比较复发自由度（FFR）。中位随访时间为38个月（14-72个月）。结果：共包括27例胸腺增生，41例低危胸腺瘤（LRT）（A、AB、B1型），48例高危胸腺瘤（HRT）（B2、B3型胸腺瘤和癌）。HRT的SUVmax、SUVmean、SUVpeak、rPET、qPET和T/M均显著高于LRT和增生（p < 0.001）。LRT患者TLG和MTV均显著增高（p < 0.001）。HRT中只有rPET、qPET和T/M显著高于LRT亚组（p = 0.042、p = 0.049和p = 0.028）。SUVmax、SUVmean和SUVpeak截止值分别< 4.3、< 2.87和4.03，显著区分FFR较长的患者（p = 0.009、p = 0.05和p = 0.05）。结论：正电子发射断层扫描（PET）代谢参数有助于胸腺组织类型的鉴别。基于标准化摄取值（SUV）的参数有望预测复发性疾病。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molecular Diagnosis & Therapy 医学-药学

CiteScore

7.80

自引率

2.50%

发文量

审稿时长

>12 weeks

期刊介绍： Molecular Diagnosis & Therapy welcomes current opinion articles on emerging or contentious issues, comprehensive narrative reviews, systematic reviews (as outlined by the PRISMA statement), original research articles (including short communications) and letters to the editor. All manuscripts are subject to peer review by international experts.