Signature of collagen alpha-1(x) gene expression in human cancers and their therapeutic implications

IF 2.9 4区医学 Q2 PATHOLOGY

Pathology, research and practice Pub Date : 2025-02-01 DOI:10.1016/j.prp.2025.155811

Akshaya Nagarajan , Varsha Varadhan , Monica Shri Manikandan , Kumaravel Kaliaperumal , Thirunavukkarasu Palaniyandi , Senthilkumar Kaliamoorthy , Gomathy Baskar , Safia Obaidur Rab , Vishal M Balaramnavar , Saravanan Kumarasamy

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Abstract

Cancers are a class of disorders that entail uncontrollably unwanted cell development with dissemination. One in six fatalities globally is attributed to cancer, a global health issue. The analysis of the entire DNA sequence and how it expresses itself in tumor cells is known as cancer genomics. The development of novel cancer treatments has been facilitated because of the genomics method. COL10A1 gene, a short chain collagen, and an interstitial matrix component, acts as a predictive biomarker for cancer prognosis. Recognizing the fundamental consequences of mutations in the COL10A1 gene and its expression in cancer is crucial. Analyzing the COL10A1 gene expression with a data set and gene expression patterns shows the level of display of the tumor. Examining the therapeutic techniques of COL10A1 gene expression leads to early detection, screening, radiation therapy, and advanced developments. This review highlights the value of the COL10A1 gene in breast, gastric, pancreatic, lung, and colorectal cancers, emphasizing its role in gene expression patterns and therapeutic techniques.

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胶原α -1(x)基因在人类癌症中的表达及其治疗意义。

癌症是一类疾病，导致不受控制的不需要的细胞发育和传播。全球六分之一的死亡归因于癌症，这是一个全球性的健康问题。对整个DNA序列及其在肿瘤细胞中如何表达的分析被称为癌症基因组学。基因组学方法促进了新型癌症治疗方法的发展。COL10A1基因是一种短链胶原蛋白，是一种间质基质成分，可作为预测癌症预后的生物标志物。认识到COL10A1基因突变的基本后果及其在癌症中的表达是至关重要的。利用数据集和基因表达模式分析COL10A1基因表达，显示肿瘤的显示水平。检查COL10A1基因表达的治疗技术导致早期检测，筛查，放射治疗和先进的发展。本文综述了COL10A1基因在乳腺癌、胃癌、胰腺癌、肺癌和结直肠癌中的价值，强调了其在基因表达模式和治疗技术中的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pathology, research and practice 医学-病理学

CiteScore

5.00

自引率

3.60%

发文量

405

审稿时长

24 days

期刊介绍： Pathology, Research and Practice provides accessible coverage of the most recent developments across the entire field of pathology: Reviews focus on recent progress in pathology, while Comments look at interesting current problems and at hypotheses for future developments in pathology. Original Papers present novel findings on all aspects of general, anatomic and molecular pathology. Rapid Communications inform readers on preliminary findings that may be relevant for further studies and need to be communicated quickly. Teaching Cases look at new aspects or special diagnostic problems of diseases and at case reports relevant for the pathologist''s practice.