The effects of weight- and non-weight-bearing exercise on corticospinal axon sprouting, regeneration-related proteins and functional recovery after spinal cord contusion.
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引用次数: 0
Abstract
The purpose of this study was to investigate the effects of weight- and non-weight-bearing exercises on the Basso-Beattie-Bresnahan (BBB) locomotor rating scale, corticospinal axon regrowth and regeneration-related proteins following spinal cord injury (SCI). Twenty-four male Sprague-Dawley rats were randomly divided into four groups: control group (n=6), SCI+sedentary group (SED, n=6), SCI+treadmill exercise group (TREAD, n=6), and SCI+swimming exercise group (SWIM, n=6). All rats in the SCI group were given the rest for 2 weeks after SCI, and then they were allowed to engage in low-intensity exercise for 6 weeks on treadmill device. Motor function (BBB score) was improved more in the SWIM group compared to the SED group at 3 and 6 weeks after SCI. The SWIM group also showed higher levels of axonal outgrowth in corticospinal tract and increased expression of phosphorylated extracellular signal-regulated kinase, a marker of axonal regeneration in the dorsal horn of the caudal region, compared to the TREAD group. Additionally, the SWIM group significantly upregulated the expression of regeneration-related proteins. Our findings suggest that non-weight-bearing exercise may be one of several rehabilitation methods for improving locomotor function and corticospinal axon regeneration after SCI.
期刊介绍：
The Journal of Exercise Rehabilitation is the official journal of the Korean Society of Exercise Rehabilitation, and is published six times a year. Supplementary issues may be published. Its official abbreviation is "J Exerc Rehabil". It was launched in 2005. The title of the first volume was Journal of the Korean Society of Exercise Rehabilitation (pISSN 1976-6319). The journal title was changed to Journal of Exercise Rehabilitation from Volume 9 Number 2, 2013. The effects of exercise rehabilitation are very broad and in some cases exercise rehabilitation has different treatment areas than traditional rehabilitation. Exercise rehabilitation can be presented as a solution to new diseases in modern society and it can replace traditional medicine in economically disadvantaged areas. Exercise rehabilitation is very effective in overcoming metabolic diseases and also has no side effects. Furthermore, exercise rehabilitation shows new possibility for neuropsychiatric diseases, such as depression, autism, attention deficit hyperactivity disorder, schizophrenia, etc. The purpose of the Journal of Exercise Rehabilitation is to identify the effects of exercise rehabilitation on a variety of diseases and to identify mechanisms for exercise rehabilitation treatment. The Journal of Exercise Rehabilitation aims to serve as an intermediary for objective and scientific validation on the effects of exercise rehabilitation worldwide. The types of manuscripts include research articles, review articles, and articles invited by the Editorial Board. The Journal of Exercise Rehabilitation contains 6 sections: Basic research on exercise rehabilitation, Clinical research on exercise rehabilitation, Exercise rehabilitation pedagogy, Exercise rehabilitation education, Exercise rehabilitation psychology, and Exercise rehabilitation welfare.
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