Autophagy intersection: Unraveling the role of the SNARE complex in lysosomal fusion in Alzheimer's disease.

IF 3.4 3区 医学 Q2 NEUROSCIENCES
Siyu Li, Yangyang Wang, Xiao Liang, Yu Li
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引用次数: 0

Abstract

Autophagy is a fundamental cellular process critical for maintaining neuronal health, particularly in the context of neurodegenerative diseases such as Alzheimer's disease (AD). This review explores the intricate role of the SNARE complex in the fusion of autophagosomes with lysosomes, a crucial step in autophagic flux. Disruptions in this fusion process, often resulting from aberrant SNARE complex function or impaired lysosomal acidification, contribute to the pathological accumulation of autophagosomes and lysosomes observed in AD. We examine the composition, regulation, and interacting molecules of the SNARE complex, emphasizing its central role in autophagosome-lysosome fusion. Furthermore, we discuss the potential impact of specific SNARE protein mutations and the broader implications for neuronal health and disease progression. By elucidating the molecular mechanisms underlying SNARE-mediated autophagic fusion, we aim to highlight therapeutic targets that could restore autophagic function and mitigate the neurodegenerative processes characteristic of AD.

自噬交叉:揭示SNARE复合物在阿尔茨海默病溶酶体融合中的作用。
自噬是维持神经元健康的基本细胞过程,特别是在阿尔茨海默病(AD)等神经退行性疾病的背景下。这篇综述探讨了SNARE复合物在自噬体与溶酶体融合中的复杂作用,这是自噬通量的关键步骤。这种融合过程的中断,通常是由于SNARE复合物功能异常或溶酶体酸化受损,导致AD中观察到的自噬体和溶酶体的病理性积累。我们研究了SNARE复合物的组成、调控和相互作用分子,强调其在自噬体-溶酶体融合中的核心作用。此外,我们讨论了特定SNARE蛋白突变的潜在影响以及对神经元健康和疾病进展的更广泛影响。通过阐明snar介导的自噬融合的分子机制,我们旨在发现能够恢复自噬功能和减轻AD神经退行性过程特征的治疗靶点。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Alzheimer's Disease
Journal of Alzheimer's Disease 医学-神经科学
CiteScore
6.40
自引率
7.50%
发文量
1327
审稿时长
2 months
期刊介绍: The Journal of Alzheimer''s Disease (JAD) is an international multidisciplinary journal to facilitate progress in understanding the etiology, pathogenesis, epidemiology, genetics, behavior, treatment and psychology of Alzheimer''s disease. The journal publishes research reports, reviews, short communications, hypotheses, ethics reviews, book reviews, and letters-to-the-editor. The journal is dedicated to providing an open forum for original research that will expedite our fundamental understanding of Alzheimer''s disease.
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