Detection and characterisation of high pathogenicity avian influenza virus (H5N1/H5N8) clade 2.3.4.4b, Hong Kong SAR, China, 2021 to 2024.

IF 9.9 2区医学 Q1 INFECTIOUS DISEASES

Eurosurveillance Pub Date : 2025-01-01 DOI:10.2807/1560-7917.ES.2025.30.1.2400839

Wanying Sun, Ka Tim Choy, Ka Man Cheng, Christopher J Brackman, Samuel Ms Cheng, Thomas Hc Sit, Anne Cn Tse, Leslie D Sims, Haogao Gu, Amy Wy Tang, Andrew Nc Wong, Andrew Tl Tsang, Joe Ct Koo, Leo Lh Luk, Hui-Ling Yen, Malik Peris, Leo Lm Poon

引用次数: 0

Abstract

We isolated three genotypes of highly pathogenic avian influenza virus (HPAIV) clade 2.3.4.4b from wild birds infected with H5N1 (n = 12) and H5N8 (n = 1) in Hong Kong SAR 2021-2024. Viruses from two spoonbills from late 2022 were genetically related to a virus from a human in China. Four tested viruses exhibited variable virulence in mice but were susceptible to approved antivirals. No neutralising antibody was detected in 63 age-stratified human sera, suggesting potential risk should the virus adapt to humans.

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2021 ~ 2024年中国香港地区高致病性禽流感病毒（H5N1/H5N8）进化枝2.3.4.4b的检测与特征分析

从香港特别行政区2021-2024年感染H5N1 （n = 12）和H5N8 （n = 1）的野生鸟类中分离到高致病性禽流感病毒（HPAIV）进化枝2.3.4.4b 3个基因型。2022年底两只琵鹭身上的病毒与中国一名人类身上的病毒有遗传关系。四种测试病毒在小鼠中表现出不同的毒力，但对批准的抗病毒药物敏感。在63个按年龄分层的人血清中未检测到中和抗体，这表明如果病毒适应人类，可能存在潜在风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Eurosurveillance INFECTIOUS DISEASES-

CiteScore

32.70

自引率

2.10%

发文量

430

审稿时长

3-8 weeks

期刊介绍： Eurosurveillance is a European peer-reviewed journal focusing on the epidemiology, surveillance, prevention, and control of communicable diseases relevant to Europe.It is a weekly online journal, with 50 issues per year published on Thursdays. The journal includes short rapid communications, in-depth research articles, surveillance reports, reviews, and perspective papers. It excels in timely publication of authoritative papers on ongoing outbreaks or other public health events. Under special circumstances when current events need to be urgently communicated to readers for rapid public health action, e-alerts can be released outside of the regular publishing schedule. Additionally, topical compilations and special issues may be provided in PDF format.