Modified Taohong Siwu Decoction Improved Cardiac Function after Myocardial Infarction by Activating PI3K/Akt Signaling Pathway.

IF 2.6 4区医学 Q2 PHARMACOLOGY & PHARMACY

Current pharmaceutical design Pub Date : 2025-01-07 DOI:10.2174/0113816128341178241028062518

Han Li, Zhi-Rong Luo, Meng-Ying Huang, Hao Cai, Ping-Ping Lu, Yan-Wu Xu, Ming-Jie Li, Hai-Dong Guo

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引用次数: 0

Abstract

Introduction: Taohong Siwu decoction (THSWD), a traditional prescription for enhancing blood circulation and eliminating blood stasis, primarily comprises peach kernel, safflower, angelica, chuanxiong, and rehmannia. Modified Taohong Siwu decoction (MTHSWD), an advanced version of THSWD, incorporates additional ingredients such as epimedium, cinnamon, and salvia miltiorrhiza. This addition serves to augment its efficacy in warming yang and promoting blood circulation. MTHSWD has excellent heart protection in cardiac damage, which indicates a promising application prospect. However, the mechanisms are yet unclear.

Methods: In this study, network pharmacology and molecular docking studies demonstrated that the effects of MTHSWD may be significantly influenced by the PI3K/Akt signaling pathway. In addition, to verify this mechanism, three groups were divided and randomly selected from among the 35 Sprague-Dawley rats: Myocardial infarction (MI) group, THSWD group, and MTHSWD group.

Results: MTHSWD greatly improved fractional shortening as well as ejection fraction and reduced the infarct size. MTHSWD attenuated cell apoptosis by activating the Akt pathway in infarcted areas. In vitro, the cytoprotective effects of MTHSWD on H9C2 cells were significantly attenuated when PI3K/Akt was inhibited.

Conclusion: Therefore, the study found that MTHSWD had a positive effect on heart function after myocardial infarction by activating the Akt pathway.

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来源期刊

Current pharmaceutical design 医学-药学

CiteScore

6.30

自引率

0.00%

发文量

302

审稿时长

2 months

期刊介绍： Current Pharmaceutical Design publishes timely in-depth reviews and research articles from leading pharmaceutical researchers in the field, covering all aspects of current research in rational drug design. Each issue is devoted to a single major therapeutic area guest edited by an acknowledged authority in the field. Each thematic issue of Current Pharmaceutical Design covers all subject areas of major importance to modern drug design including: medicinal chemistry, pharmacology, drug targets and disease mechanism.