Genetically Engineered Hypoimmune Human Muscle Progenitor Cells Can Reduce Immune Rejection.

IF 5.9 1区生物学 Q2 CELL BIOLOGY

Cell Proliferation Pub Date : 2025-01-07 DOI:10.1111/cpr.13802

Yu Chen, Peng Wang, Shilin Ma, Chenran Yue, Xupeng Liu, Yeqian Cheng, Kun Liu, Tongbiao Zhao, Ng Shyh-Chang

引用次数: 0

Abstract

Cells face two challenges after transplantation: recognition and killing by lymphocytes, and cell apoptosis induced by the transplantation environment. Our hypoimmune cells aim to address these two challenges through editing of immunomodulatory proteins and overexpression of anti-apoptotic proteins.

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基因工程的低免疫人类肌肉祖细胞可以减少免疫排斥。

细胞移植后面临两大挑战：淋巴细胞的识别和杀伤，以及移植环境诱导的细胞凋亡。我们的低免疫细胞旨在通过编辑免疫调节蛋白和过表达抗凋亡蛋白来解决这两个挑战。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell Proliferation 生物-细胞生物学

CiteScore

14.80

自引率

2.40%

发文量

198

审稿时长

1 months

期刊介绍： Cell Proliferation Focus: Devoted to studies into all aspects of cell proliferation and differentiation. Covers normal and abnormal states. Explores control systems and mechanisms at various levels: inter- and intracellular, molecular, and genetic. Investigates modification by and interactions with chemical and physical agents. Includes mathematical modeling and the development of new techniques. Publication Content: Original research papers Invited review articles Book reviews Letters commenting on previously published papers and/or topics of general interest By organizing the information in this manner, readers can quickly grasp the scope, focus, and publication content of Cell Proliferation.