The effect of preoperative topical magnesium sulfate spraying in the oropharyngeal region on postoperative sore throat following gynecological laparoscopic surgery: a randomized clinical trial.

IF 2.3 3区医学 Q2 ANESTHESIOLOGY

BMC Anesthesiology Pub Date : 2025-01-08 DOI:10.1186/s12871-025-02893-7

Linxin Wang, Fangfang Li, Yuqing Liu, Xingyu Xiong, Qin Qiu, Guanglei Wang

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引用次数: 0

Abstract

Background: Postoperative sore throat is a common complication following general anesthesia. This study aimed to investigate the impact of preoperative topical magnesium sulfate spraying in the oropharyngeal region on postoperative sore throat following gynecological laparoscopic surgery.

Methods: The study included 58 patients scheduled for gynecologic laparoscopic surgery at Xuzhou Medical University Affiliated Hospital. Patients were randomly assigned to either the magnesium sulfate group or the control group, with 29 patients in each group. In the magnesium sulfate group, 25% magnesium sulfate was sprayed at a dose of 15 mg/kg on the mucous membrane of the pharynx and posterior wall of the larynx near the glottis using a laryngoscope under visual guidance during intubation; in the control group, an equal volume of normal saline was used instead. The primary outcome measure was the overall incidence of postoperative sore throat 48 h after surgery.

Results: The overall incidence of postoperative sore throat in the magnesium sulfate group was lower than that in the the control group (20.0% vs. 66.7%, P < 0.001). At time points T1 (P < 0.001), T2 (P = 0.02), and T3 (P = 0.015), the incidence of postoperative sore throat in the the magnesium sulfate group was also lower than that in the the control group.

Conclusion: This study confirmed that preoperatively spraying magnesium sulfate locally in the Oropharyngeal Region can reduce the frequency and severity of postoperative sore throat.

Trial registration: The study was registered at Chictr.org.cn with the number ChiCTR2400087240 on 07/23/2024.

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一项随机临床试验：术前口咽区外用硫酸镁喷涂对妇科腹腔镜术后喉咙痛的影响

背景：术后喉咙痛是全身麻醉后常见的并发症。本研究旨在探讨术前口咽区局部喷施硫酸镁对妇科腹腔镜术后咽喉痛的影响。方法：选取徐州医科大学附属医院妇科腹腔镜手术58例患者为研究对象。患者随机分为硫酸镁组和对照组，每组29例。硫酸镁组插管时在目视引导下喉镜下将25%硫酸镁以15 mg/kg的剂量喷于声门附近咽部粘膜及喉后壁；对照组用等量生理盐水代替。主要结局指标是术后48小时喉咙痛的总发生率。结果：硫酸镁组术后咽痛发生率总体低于对照组（20.0% vs. 66.7%）。结论：本研究证实术前口咽区局部喷施硫酸镁可降低术后咽痛发生频率和严重程度。试验注册：本研究于2024年7月23日在Chictr.org.cn注册，注册号为ChiCTR2400087240。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

BMC Anesthesiology ANESTHESIOLOGY-

CiteScore

3.50

自引率

4.50%

发文量

349

审稿时长

>12 weeks

期刊介绍： BMC Anesthesiology is an open access, peer-reviewed journal that considers articles on all aspects of anesthesiology, critical care, perioperative care and pain management, including clinical and experimental research into anesthetic mechanisms, administration and efficacy, technology and monitoring, and associated economic issues.