[Advances in inhibitory ion channel glycine receptors].

Q3 Medicine

生理学报 Pub Date : 2024-12-25

Xu-Ke Pang, Si Chen, Xiang-Xian Ma, Yi-Nuo Xu, Wei-Jie Bai, Chong-Lei Fu, Gui-Chang Zou

引用次数: 0

Abstract

Glycine receptors (GlyRs) belong to the ligand-gated ion channel receptor superfamily and are widely distributed throughout the central nervous system. GlyRs are essential for maintaining visual, auditory, sensory and motor functions, and abnormalities in its structure and function can lead to various neurological disorders. This review aims to provide an extensive analysis of the structure, function and regulatory mechanisms of GlyRs, and evaluate its role in various central nervous system diseases. Ultimately, this review will provide theoretical support for the development of novel drugs specifically targeting GlyRs.

本刊更多论文

抑制离子通道甘氨酸受体的研究进展

甘氨酸受体（Glycine receptor, GlyRs）属于配体门控离子通道受体超家族，广泛分布于中枢神经系统。glyr对于维持视觉、听觉、感觉和运动功能至关重要，其结构和功能异常可导致各种神经系统疾病。本文旨在对GlyRs的结构、功能和调控机制进行深入分析，并探讨其在各种中枢神经系统疾病中的作用。最终，本综述将为开发特异性靶向GlyRs的新药提供理论支持。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

生理学报 Medicine-Medicine (all)

CiteScore

1.20

自引率

0.00%

发文量

4820

期刊介绍： Acta Physiologica Sinica (APS) is sponsored by the Chinese Association for Physiological Sciences and Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences (CAS), and is published bimonthly by the Science Press, China. APS publishes original research articles in the field of physiology as well as research contributions from other biomedical disciplines and proceedings of conferences and symposia of physiological sciences. Besides “Original Research Articles”, the journal also provides columns as “Brief Review”, “Rapid Communication”, “Experimental Technique”, and “Letter to the Editor”. Articles are published in either Chinese or English according to authors’ submission.