Lung function-associated exposome profile in the era of climate change: Pooled analysis of 8 population-based European cohorts within the EXPANSE project

IF 10.3 1区环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES

Environment International Pub Date : 2025-02-01 DOI:10.1016/j.envint.2025.109269

Ayoung Jeong , Gianfranco Lovison , Alonso Bussalleu , Marta Cirach , Payam Dadvand , Kees de Hoogh , Claudia Flexeder , Gerard Hoek , Medea Imboden , Stefan Karrasch , Gerard H. Koppelman , Sara Kress , Petter Ljungman , Renata Majewska , Göran Pershagen , Regina Pickford , Youchen Shen , Roel C.H. Vermeulen , Jelle J. Vlaanderen , Megi Vogli , Nicole Probst-Hensch

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引用次数: 0

Abstract

Background

The independent and interrelated long-term effects of the exposome such as air pollution, greenness, and ambient temperature on lung function are not well understood, yet relevant in the light of climate change.

Methods

Pre-bronchodilation FEV1 from five mature birth cohorts (N = 4724) and three adult cohorts (N = 6052) from five European countries were used to assess cross-sectional associations with air pollution, greenness, and ambient temperature, assigned to their residential address. All two-way interactions and square terms were a priori included in building the final elastic net regression model. Elastic net regression results were put into the context of different environmental scenarios such as improvement of air quality, improvement of greenness, climate change, or their combinations.

Results

Elastic net regression of FEV1 z-scores identified non-zero coefficients for many interaction terms, indicating the importance of joint effects of exposure to air pollution, greenness, and temperature. The non-zero coefficients were bigger and more stable in adults than in children. Upon exploring lung function benefits for different environmental scenarios, an improvement of FEV1 was expected in the scenario of improving air quality or greenness. In contrast, negative changes in FEV1 z-scores were expected in the scenario of climate change, characterized by daily temperature increase in summer and decrease in winter. The beneficial FEV1 effects of improving air pollution or greenness were attenuated in the presence of climate change.

Conclusion

Complex exposome profiles of long-term exposure to air pollution, greenness, and temperature showed associations with FEV1 in European adults, and to less extent in children and adolescents. Climate change seems to have a negative impact on lung function and modifies the association of air pollution and greenspace with lung function.

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气候变化时代肺功能相关暴露谱：对欧洲8个以人群为基础的队列进行了汇总分析

空气污染、绿色度和环境温度等暴露因素对肺功能的独立和相互关联的长期影响尚不清楚，但与气候变化有关。方法采用来自5个欧洲国家的5个成熟出生队列（N = 4724）和3个成人队列（N = 6052）的支气管扩张前FEV1，评估其与居住地址的空气污染、绿色度和环境温度的横断面关联。所有双向相互作用和平方项都先验地包含在最终弹性网络回归模型的构建中。将弹性网回归结果置于不同环境情景的背景下，如空气质量改善、绿化改善、气候变化或它们的组合。结果FEV1 z分数的弹性净回归识别出许多相互作用项的非零系数，表明暴露于空气污染，绿色和温度的联合效应的重要性。非零系数在成人中比在儿童中更大更稳定。在探索不同环境情景下肺功能的效益后，预计空气质量或绿化改善情景下FEV1会有所改善。而在气候变化情景下，FEV1 z分数呈夏季日升高、冬季日降低的负变化。在气候变化的影响下，改善空气污染或绿化的有利FEV1效应被减弱。结论欧洲成年人长期暴露于空气污染、绿色环境和温度的复杂暴露特征与FEV1存在关联，而儿童和青少年的关联程度较低。气候变化似乎对肺功能有负面影响，并改变了空气污染和绿地与肺功能的关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Environment International 环境科学-环境科学

CiteScore

21.90

自引率

3.40%

发文量

734

审稿时长

2.8 months

期刊介绍： Environmental Health publishes manuscripts focusing on critical aspects of environmental and occupational medicine, including studies in toxicology and epidemiology, to illuminate the human health implications of exposure to environmental hazards. The journal adopts an open-access model and practices open peer review. It caters to scientists and practitioners across all environmental science domains, directly or indirectly impacting human health and well-being. With a commitment to enhancing the prevention of environmentally-related health risks, Environmental Health serves as a public health journal for the community and scientists engaged in matters of public health significance concerning the environment.