Piezo1 as a therapeutic target for glucocorticoid-induced osteoporosis

IF 29.4 1区医学 Q1 RHEUMATOLOGY

Nature Reviews Rheumatology Pub Date : 2025-01-10 DOI:10.1038/s41584-024-01215-4

Holly Webster

引用次数: 0

Abstract

A study implicates the Hes1–Piezo1 signalling pathway in osteocytes in the pathogenesis of glucocorticoid-induced osteoporosis and demonstrates the beneficial effects of Yoda1, a Piezo1 agonist.

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Piezo1作为糖皮质激素所致骨质疏松症的治疗靶点

一项研究提示骨细胞Hes1-Piezo1信号通路参与糖皮质激素诱导骨质疏松的发病机制，并证实了Piezo1激动剂Yoda1的有益作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Reviews Rheumatology 医学-风湿病学

CiteScore

29.90

自引率

0.90%

发文量

137

审稿时长

6-12 weeks

期刊介绍： Nature Reviews Rheumatology is part of the Nature Reviews portfolio of journals. The journal scope covers the entire spectrum of rheumatology research. We ensure that our articles are accessible to the widest possible audience.