Aleksandra Rudzka, Tamara Reiter, Prof. Wolfgang Kroutil, Dr. Paweł Borowiecki
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引用次数: 0
Abstract
A two-enzyme-catalyzed dynamic kinetic resolution (DKR) of racemic secondary alcohols in water was achieved by Wolfgang Kroutil, Paweł Borowiecki, and co-workers (e202420133). The cover image illustrates the cooperative action of an engineered alcohol dehydrogenase (bottom left), which mediates racemization via a hydrogen-borrowing mechanism (indicated by the swirl), and an acyltransferase (bottom right) that enables enantioselective acylation. This organic-solvent- and metal-free DKR offers a novel approach for the deracemization of sec-alcohols in an aqueous system using exclusively biocatalysts. The cover was designed by Verena Resch.
期刊介绍：
Angewandte Chemie, a journal of the German Chemical Society (GDCh), maintains a leading position among scholarly journals in general chemistry with an impressive Impact Factor of 16.6 (2022 Journal Citation Reports, Clarivate, 2023). Published weekly in a reader-friendly format, it features new articles almost every day. Established in 1887, Angewandte Chemie is a prominent chemistry journal, offering a dynamic blend of Review-type articles, Highlights, Communications, and Research Articles on a weekly basis, making it unique in the field.
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