Divergent roles for propionate and butyrate in colorectal cancer epigenetics

IF 18.9 1区医学 Q1 ENDOCRINOLOGY & METABOLISM

Nature metabolism Pub Date : 2025-01-09 DOI:10.1038/s42255-024-01186-6

Yuen Jian Cheong, Sophie Trefely

引用次数: 0

Abstract

The intestinal short chain fatty acids (SCFAs) propionate and butyrate directly contribute to epigenetic regulation by supplying precursor molecules for histone lysine modifications. Nshanian et al. examine how propionate and butyrate supplementation affects gene regulation in colorectal cancer (CRC) cells, revealing distinct effects for each. Comparing normal cells with cancer cells shows context-dependent responses that might inform metabolic interventions.

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丙酸盐和丁酸盐在结直肠癌表观遗传学中的不同作用

肠道短链脂肪酸丙酸酯和丁酸酯通过提供组蛋白赖氨酸修饰的前体分子直接参与表观遗传调控。Nshanian等人研究了丙酸盐和丁酸盐补充剂如何影响结直肠癌（CRC）细胞的基因调控，揭示了它们各自的不同作用。将正常细胞与癌细胞进行比较显示出可能为代谢干预提供信息的环境依赖性反应。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature metabolism ENDOCRINOLOGY & METABOLISM-

CiteScore

27.50

自引率

2.40%

发文量

170

期刊介绍： Nature Metabolism is a peer-reviewed scientific journal that covers a broad range of topics in metabolism research. It aims to advance the understanding of metabolic and homeostatic processes at a cellular and physiological level. The journal publishes research from various fields, including fundamental cell biology, basic biomedical and translational research, and integrative physiology. It focuses on how cellular metabolism affects cellular function, the physiology and homeostasis of organs and tissues, and the regulation of organismal energy homeostasis. It also investigates the molecular pathophysiology of metabolic diseases such as diabetes and obesity, as well as their treatment. Nature Metabolism follows the standards of other Nature-branded journals, with a dedicated team of professional editors, rigorous peer-review process, high standards of copy-editing and production, swift publication, and editorial independence. The journal has a high impact factor, has a certain influence in the international area, and is deeply concerned and cited by the majority of scholars.