An unexpected Lewis acid-catalyzed cascade reaction of bicyclo[1.1.0]butanes with triazinanes toward biscyclobutenyl amines†

Abstract

An unexpected In(OTf)₃-catalyzed cascade reaction of bicyclo[1.1.0]butanes with triazinanes is reported, providing a series of butterfly-shaped biscyclobutenyl amines in good yields. This reaction features simple operation, mild reaction conditions, and broad substrate scope. A rational mechanism involving a key carbocation intermediate is proposed.