Remodelling molecular frameworks via atom-level surgery: recent advances in skeletal editing of (hetero)cycles

Rubal Sharma , Mitsuhiro Arisawa , Shinobu Takizawa , Mohamed S. H. Salem
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引用次数: 0

Abstract

Skeletal editing is an emerging approach in synthetic chemistry that enables precise atom-level modifications within molecular cores, facilitating complex transformations and minimizing resource-intensive synthesis. This review provides a comprehensive overview of the most recent advancements in skeletal editing, with a particular focus on single atom modifications. While skeletal editing can be applied to both cyclic and acyclic compounds, this review centers on carbo- and heterocyclic systems exclusively. By integrating historical context and categorizing key developments, it highlights the major achievements in insertion, deletion, and transmutation, connecting related works and delving into mechanistic insights.

Abstract Image

通过原子水平手术重塑分子框架:(异)周期骨骼编辑的最新进展
骨架编辑是合成化学中的一种新兴方法,可以在分子核心内进行精确的原子级修饰,促进复杂的转化并最大限度地减少资源密集型合成。这篇综述提供了骨骼编辑的最新进展的全面概述,特别关注单原子修饰。虽然骨架编辑可以应用于环和非环化合物,但本综述仅集中在碳和杂环系统上。通过整合历史背景和对关键发展进行分类,突出了插入、删除和嬗变方面的主要成就,连接了相关作品,并深入探讨了机制见解。
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CiteScore
7.80
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0.00%
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