Airborne Staphylococcus aureus Exposure Induces Depression-like Behaviors in Mice via Abnormal Neural Oscillation and Mitochondrial Dysfunction

IF 10.8 1区 环境科学与生态学 Q1 ENGINEERING, ENVIRONMENTAL
Jie Gao, Li Pan, Pengxiang Li, Jing Liu, Ziye Yang, Shushuai Yang, Bin Han, Ping Liu, Can Wang, Liqun Chen, Guangbo Qu, Guibin Jiang
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Abstract

Airborne Staphylococcus aureus exists widely in the natural environment and is closely related to human health. Growing evidence indicates that environmental air pollution elevates the risk of depressive disorders. However, the potential role of airborne S. aureus in the development of depression remains unclear. This study aims to elucidate the neurotoxic effects and potential mechanisms associated with depression caused by airborne S. aureus. Mice were randomly divided into four groups, and the experimental groups with environmental S. aureus were at 4.89 × 102, 8.89 × 105, and 1.27 × 108 CFU/m3 during four consecutive weeks. Airborne S. aureus exposure contributed to depression-like behaviors in mice, especially in the high-concentration group. The electroencephalography signal analysis identified uncoupling of theta and gamma bands and a shift of the beta rhythm toward delta oscillation in the medial prefrontal cortex of mice. Neuropathological analysis showed uplifted neuroinflammation and elevated levels of oxidative stress in the brain. Neuroinflammation and oxidative stress resulted in mitochondrial dysfunction, which could lead to apoptosis. Together, this study provides a strong basis for understanding the adverse outcomes of airborne S. aureus on mental health disorders.

Abstract Image

空气中的金黄色葡萄球菌广泛存在于自然环境中,与人类健康密切相关。越来越多的证据表明,环境空气污染会增加患抑郁症的风险。然而,空气中的金黄色葡萄球菌在抑郁症发病中的潜在作用仍不清楚。本研究旨在阐明空气中的金黄色葡萄球菌对神经系统的毒性作用以及与抑郁症相关的潜在机制。小鼠被随机分为四组,实验组的环境金黄色葡萄球菌含量分别为 4.89 × 102、8.89 × 105 和 1.27 × 108 CFU/m3,连续四周。接触空气中的金黄色葡萄球菌会导致小鼠出现抑郁样行为,尤其是在高浓度组。脑电图信号分析发现,小鼠内侧前额叶皮层的θ和γ波段不耦合,β节律向δ振荡转移。神经病理学分析表明,大脑中的神经炎症和氧化应激水平升高。神经炎症和氧化应激导致线粒体功能障碍,从而导致细胞凋亡。总之,这项研究为了解空气中的金黄色葡萄球菌对精神疾病的不良影响提供了坚实的基础。
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来源期刊
环境科学与技术
环境科学与技术 环境科学-工程:环境
CiteScore
17.50
自引率
9.60%
发文量
12359
审稿时长
2.8 months
期刊介绍: Environmental Science & Technology (ES&T) is a co-sponsored academic and technical magazine by the Hubei Provincial Environmental Protection Bureau and the Hubei Provincial Academy of Environmental Sciences. Environmental Science & Technology (ES&T) holds the status of Chinese core journals, scientific papers source journals of China, Chinese Science Citation Database source journals, and Chinese Academic Journal Comprehensive Evaluation Database source journals. This publication focuses on the academic field of environmental protection, featuring articles related to environmental protection and technical advancements.
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