Quantitative evaluation of dynamic glymphatic activity in insomnia: A contrast-enhanced synthetic MRI study

IF 3.8 2区医学 Q1 CLINICAL NEUROLOGY

Sleep medicine Pub Date : 2025-01-02 DOI:10.1016/j.sleep.2024.12.038

Ruifang Xiong , Jie Feng , Hanting Zhu , Chengyi Li , Pengxin Hu , Yu Zou , Mingyu Zhou , Ye Wang , Xiaoping Tang

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引用次数: 0

Abstract

Background

Sleep is associated with glymphatic circulation activity; however, there is no direct imaging modality to validate glymphatic circulation disorders in patients with insomnia. Therefore, this study aimed to explore the relationship between insomnia disorder (ID) and the glymphatic system. Dynamic synthetic magnetic resonance imaging (syMRI) was performed.

Methods

Thirty-two patients with insomnia and ten healthy volunteers were prospectively recruited from the Second Affiliated Medical Hospital of Nanchang University, China. All subjects underwent syMRI at baseline (0 h), 0.5 h, 1 h, 1.5 h, 12 h, and 3 d after enhancement. The MAGiC post-processing workstation was used to measure T1 signal changes in different brain regions, peak ΔT1, and slopes at different time periods. All patients with insomnia underwent polysomnography (PSG) and were evaluated using the Pittsburgh Sleep Quality Index (PSQI). Repeated measures analysis of variance, Bonferroni multiple comparison, Shapiro-Wilk test, t-test, and Pearson or Spearman correlation analysis were used.

Results

The main effect of T1 values for the cerebral white matter, cerebral gray matter, putamen, thalamus, and cerebellar white matter at different measurement times were significant in all subjects (all p < 0.05). The T1 values of the insula gray matter at 0.5 h were statistically different between the insomnia group and the control group (1231.76 ± 9.42 vs. 1272.95 ± 16.86 ms; p = 0.005), and the T1 values of the hippocampal gray matter at 3 d were different between the two groups (1198.24 ± 9.01 vs. 1234.55 ± 16.12 ms; p = 0.025). The time-varying curves of the T1 values in the cerebral gray matter and putamen were statistically different between the two groups (p = 0.009, 0.026). The cerebellar gray matter slope (1–1.5 h) and thalamic slope (1–1.5 h) were statistically different between the two groups [-113 (−188.5, −28) vs. 4.739 (−2.07, 7.98); 52 (−10, 119.75) vs. −19.25 (−120, 31.50]; p = 0.048, 0.017).

Conclusion

Reduced clearance of the gadolinium-based contrast agent by the gray matter and deep nuclei indicates the presence of glymphatic system impairment in insomnia.

查看原文本刊更多论文

失眠症中动态淋巴活性的定量评价：对比增强合成MRI研究。

背景：睡眠与淋巴循环活动有关；然而，没有直接的成像方式来验证失眠患者的淋巴循环障碍。因此，本研究旨在探讨失眠障碍（ID）与淋巴系统的关系。动态合成磁共振成像（syMRI）。方法：前瞻性招募来自南昌大学第二附属医院的32例失眠症患者和10例健康志愿者。所有受试者在增强后基线（0小时）、0.5小时、1小时、1.5小时、12小时和3 d进行了syMRI检查。使用MAGiC后处理工作站测量不同时间段脑区T1信号变化、峰值ΔT1和斜率。所有失眠症患者均接受多导睡眠图（PSG）检查，并使用匹兹堡睡眠质量指数（PSQI）进行评估。采用重复测量方差分析、Bonferroni多重比较、Shapiro-Wilk检验、t检验、Pearson或Spearman相关分析。结果：不同测量时间脑白质、脑灰质、壳核、丘脑和小脑白质T1值的主效应均显著（均p）。结论：脑灰质和深部核对钆造影剂的清除率降低提示失眠患者存在淋巴系统损伤。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Sleep medicine 医学-临床神经学

CiteScore

8.40

自引率

6.20%

发文量

1060

审稿时长

49 days

期刊介绍： Sleep Medicine aims to be a journal no one involved in clinical sleep medicine can do without. A journal primarily focussing on the human aspects of sleep, integrating the various disciplines that are involved in sleep medicine: neurology, clinical neurophysiology, internal medicine (particularly pulmonology and cardiology), psychology, psychiatry, sleep technology, pediatrics, neurosurgery, otorhinolaryngology, and dentistry. The journal publishes the following types of articles: Reviews (also intended as a way to bridge the gap between basic sleep research and clinical relevance); Original Research Articles; Full-length articles; Brief communications; Controversies; Case reports; Letters to the Editor; Journal search and commentaries; Book reviews; Meeting announcements; Listing of relevant organisations plus web sites.