Cyclosporine-induced thrombotic microangiopathy in pregnant women: A case report and literature review.

IF 0.6 Q3 MEDICINE, GENERAL & INTERNAL

SAGE Open Medical Case Reports Pub Date : 2025-01-04 eCollection Date: 2025-01-01 DOI:10.1177/2050313X241308693

Su Zhang, Hai-Hui Zhou, Zi-Xing Zhong, Qi-Qi Wang, Ping Huang, Su-Xiao Liu

引用次数: 0

Abstract

Cyclosporine A (CsA) is a commonly used immunosuppressant, but its association with thrombotic microangiopathy (TMA) is rarely reported. In recent years, CsA has been used in pregnant women with autoimmune diseases or previous immune-related adverse pregnancies. Our case involves a 34-year-old female who developed typical laboratory indicators of TMA while using CsA to improve pregnancy outcomes. After discontinuing CsA, the TMA markers gradually normalized. To our knowledge, this is the first report of CsA-induced TMA during pregnancy. We also reviewed previous case reports of CsA-induced TMA and summarized the possible mechanisms, characteristics, and risk factors, as well as methods to identify this rare adverse effect of CsA in pregnant women.

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孕妇环孢素诱发的血栓性微血管病1例报告并文献复习。

环孢素 A（CsA）是一种常用的免疫抑制剂，但其与血栓性微血管病（TMA）相关的报道却很少。近年来，CsA 被用于患有自身免疫性疾病或曾有过免疫相关不良妊娠史的孕妇。我们的病例涉及一名 34 岁女性，她在使用 CsA 改善妊娠结局时出现了典型的 TMA 实验室指标。停用 CsA 后，TMA 指标逐渐恢复正常。据我们所知，这是第一例妊娠期 CsA 引起 TMA 的报告。我们还回顾了之前关于 CsA 诱导的 TMA 的病例报告，总结了可能的机制、特征和风险因素，以及鉴别这种罕见的孕妇 CsA 不良反应的方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

SAGE Open Medical Case Reports MEDICINE, GENERAL & INTERNAL-

CiteScore

0.60

自引率

0.00%

发文量

320

审稿时长

8 weeks

期刊介绍： SAGE Open Medical Case Reports (indexed in PubMed Central) is a peer reviewed, open access journal. It aims to provide a publication home for short case reports and case series, which often do not find a place in traditional primary research journals, but provide key insights into real medical cases that are essential for physicians, and may ultimately help to improve patient outcomes. SAGE Open Medical Case Reports does not limit content due to page budgets or thematic significance. Papers are subject to rigorous peer review and are selected on the basis of whether the research is sound and deserves publication. By virtue of not restricting papers to a narrow discipline, SAGE Open Medical Case Reports facilitates the discovery of the connections between papers, whether within or between disciplines. Case reports can span the full spectrum of medicine across the health sciences in the broadest sense, including: Allergy/Immunology Anaesthesia/Pain Cardiovascular Critical Care/ Emergency Medicine Dentistry Dermatology Diabetes/Endocrinology Epidemiology/Public Health Gastroenterology/Hepatology Geriatrics/Gerontology Haematology Infectious Diseases Mental Health/Psychiatry Nephrology Neurology Nursing Obstetrics/Gynaecology Oncology Ophthalmology Orthopaedics/Rehabilitation/Occupational Therapy Otolaryngology Palliative Medicine Pathology Pharmacoeconomics/health economics Pharmacoepidemiology/Drug safety Psychopharmacology Radiology Respiratory Medicine Rheumatology/ Clinical Immunology Sports Medicine Surgery Toxicology Urology Women''s Health.