Uncontrolled asthma is Associated with Increased Visceral Adipose Tissue, Decreased Bone Mineral Content, and Reduced Exercise Capacity.

IF 3.7 3区医学 Q2 ALLERGY

Journal of Asthma and Allergy Pub Date : 2024-12-31 eCollection Date: 2024-01-01 DOI:10.2147/JAA.S474667

Florence Schleich, Stéphanie Ziant, Sébastien Louis, Catherine Moermans, Rita Deroisy, Renaud Louis, Jean-François Kaux, Thierry Bury

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引用次数: 0

Abstract

Introduction: Physical inactivity due to shortness of breath is common among patients with uncontrolled asthma. We evaluated the body mass composition and exercise capacity of patients with poorly controlled asthma, despite maximal inhalation therapy.

Methods: We recruited 56 patients from the Asthma Clinic of the University Hospital of Liège between September 2020 and December 2023, and 14 healthy subjects. Patients with asthma underwent detailed investigations, including induced sputum, exercise testing, and Dual-Energy X-ray Absorptiometry (DXA), to determine overall body fat mass and fat-free mass, while healthy subjects only underwent DXA. This study was approved by the Ethics Committee (2019/362).

Results: The mean age of patients with asthma was 45 years ± 12; 58% were female, 10% were active smokers, and mean post-BD Forced Expiratory Volume in one second was 85.7% predicted. Compared to healthy subjects, asthmatics had a higher BMI (28.5±5.1 kg/m2 vs 22.5 ±2.8 kg/m2, p<0.0001) and fat mass index (FMI; 10.3 ± 3.7 vs 5.9 ± 2.8 kg/m2, p=0.0005), lower lean and bone mass (62% vs 71%, p=0.0012), and greater android fat distribution (1.00 ± 0.22 vs 0.80 ± 0.13, p<0.0001). Eosinophilic asthma (sputum eosinophil count of ≥3%) was characterized by a better VO₂ max compared to non-eosinophilic asthma (20.7 [17.8-24.3] vs 17.3 [14.0-18.9], p=0.04). Higher lean mass was correlated with better asthma control and lower depression scores. Lean mass and bone mineral content correlated with maximal expiratory, inspiratory, and maximal aerobic power.

Conclusion: Our study confirmed that patients with uncontrolled asthma were overweight and had decreased exercise capacity.

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不受控制的哮喘与内脏脂肪组织增加、骨矿物质含量降低和运动能力降低有关。

简介：呼吸短促导致的身体活动不足在未控制的哮喘患者中很常见。我们评估了控制不佳的哮喘患者的身体质量组成和运动能力，尽管进行了最大吸入治疗。方法：我们招募了2020年9月至2023年12月在巴黎大学附属医院哮喘门诊就诊的56例患者，以及14名健康受试者。哮喘患者接受了详细的调查，包括诱导痰、运动试验和双能x线吸收仪（DXA），以确定全身脂肪质量和无脂质量，而健康受试者仅接受DXA。本研究已获得伦理委员会批准（2019/362）。结果：哮喘患者平均年龄45岁±12岁；其中58%为女性，10%为活跃吸烟者，bd后平均一秒钟用力呼气量预测为85.7%。与健康受试者相比，哮喘患者的BMI（28.5±5.1 kg/m2 vs 22.5±2.8 kg/m2）高于非嗜酸性哮喘患者（20.7 [17.8-24.3]vs 17.3 [14.0-18.9], p=0.04）。较高的瘦质量与更好的哮喘控制和较低的抑郁评分相关。瘦体重和骨矿物质含量与最大呼气、吸气和最大有氧能力相关。结论：我们的研究证实，未受控制的哮喘患者体重超标，运动能力下降。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Asthma and Allergy Medicine-Immunology and Allergy

CiteScore

5.30

自引率

6.20%

发文量

185

审稿时长

16 weeks

期刊介绍： An international, peer-reviewed journal publishing original research, reports, editorials and commentaries on the following topics: Asthma; Pulmonary physiology; Asthma related clinical health; Clinical immunology and the immunological basis of disease; Pharmacological interventions and new therapies. Although the main focus of the journal will be to publish research and clinical results in humans, preclinical, animal and in vitro studies will be published where they shed light on disease processes and potential new therapies.