P S Kolesnikova, O S Pavlova, M V Gulyaev, T A Kuropatkina, Yu A Pirogov
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引用次数: 0
Abstract
Using magnetic resonance imaging (MRI) with radial scanning, images of intact rat lungs and rat lungs with pulmonary hypertension were obtained. The retrospective gating method was applied to construct images of rat lungs during inspiration and expiration phases. Lung volumes at both respiratory phases, relative tidal volume, and the percentage of lung lesions were calculated. Lung volumes at inspiration and expiration were greater by ~4 and ~18%, respectively, and the relative lung tidal volume was lower by ~2.8 times than in intact rats. Constructed fractional ventilation maps showed a ~2.6-fold decrease in ventilation values in the pathological area. Thus, the application of the retrospective gating method allows detecting changes in lung volumes and ventilation, confirming the presence of pathology and its impact on the respiratory function.
期刊介绍：
Bulletin of Experimental Biology and Medicine presents original peer reviewed research papers and brief reports on priority new research results in physiology, biochemistry, biophysics, pharmacology, immunology, microbiology, genetics, oncology, etc. Novel trends in science are covered in new sections of the journal - Biogerontology and Human Ecology - that first appeared in 2005.
World scientific interest in stem cells prompted inclusion into Bulletin of Experimental Biology and Medicine a quarterly scientific journal Cell Technologies in Biology and Medicine (a new Russian Academy of Medical Sciences publication since 2005). It publishes only original papers from the leading research institutions on molecular biology of stem and progenitor cells, stem cell as the basis of gene therapy, molecular language of cell-to-cell communication, cytokines, chemokines, growth and other factors, pilot projects on clinical use of stem and progenitor cells.
The Russian Volume Year is published in English from April.
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