Oxidative Neutralisation of Sulfur-based Chemical Warfare Agents Mediated by a Lipase: from Batch to Flow Reactor.

IF 3.9 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Chemistry - A European Journal Pub Date : 2025-01-05 DOI:10.1002/chem.202403701

Julien Legros, Maxime Boddaert, Valmir Baptista da Silva, Sergui Mansour, Daniela Vuluga, Pierre-Yves Renard, Jean-Christophe Monbaliu

引用次数: 0

Abstract

The sulfur-containing chemical warfare agents sulfur mustard HD and nerve agent VX are highly toxic and persistent in the environment. Therefore, their neutralisation requires harsh oxidation conditions, but also precise selectivity. Here we report the safe and effective detoxification of surrogates CEES and PhX by selective oxidation of the sulfur atom by generating peracetic acid from AcOEt and aq. H2O2 assisted by the supported lipase CALB. Morever, it is possible to perform these neutralisations with safe 'on demand' generation of AcOOH in a flow system by using a packed bed reactor containing the supported biocatalyst.

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来源期刊

Chemistry - A European Journal 化学-化学综合

CiteScore

7.90

自引率

4.70%

发文量

1808

审稿时长

1.8 months

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