{"title":"Small molecules unlock broad-spectrum plant resistance","authors":"Kaihuai Li, Yan Qiao, Huan Chen, Fengquan Liu","doi":"10.1038/s41477-024-01891-w","DOIUrl":null,"url":null,"abstract":"Toll/interleukin-1 receptor (TIR) domain proteins possess NADase activity and trigger plant immunity via their enzymatic products. Two recent studies have elucidated the mechanism by which TIR NADase-derived 2′cADPR and pRib-AMP/ADP activate EDS1–PAD4–ADR1 (EPA) signalling, thereby inducing immune responses in plants.","PeriodicalId":18904,"journal":{"name":"Nature Plants","volume":"96 1","pages":""},"PeriodicalIF":15.8000,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature Plants","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1038/s41477-024-01891-w","RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PLANT SCIENCES","Score":null,"Total":0}
引用次数: 0
Abstract
Toll/interleukin-1 receptor (TIR) domain proteins possess NADase activity and trigger plant immunity via their enzymatic products. Two recent studies have elucidated the mechanism by which TIR NADase-derived 2′cADPR and pRib-AMP/ADP activate EDS1–PAD4–ADR1 (EPA) signalling, thereby inducing immune responses in plants.
期刊介绍:
Nature Plants is an online-only, monthly journal publishing the best research on plants — from their evolution, development, metabolism and environmental interactions to their societal significance.