Antimicrobial resistance and epidemiological patterns of Streptococcus pyogenes in Türkiye

IF 4.7 3区医学 Q1 INFECTIOUS DISEASES

Journal of Infection and Public Health Pub Date : 2025-02-01 DOI:10.1016/j.jiph.2024.102633

Nihan Ünübol , Nese Caglayan , Sinan Cebeci , Yeşim Beşli , Banu Sancak , Neval Yurttutan Uyar , Siavosh Salmanzadeh Ahrabi , Masoud Alebouyeh , Tanıl Kocagöz

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引用次数: 0

Abstract

Background

Drug-resistant Group A beta-hemolytic streptococci remain significant infectious agents globally. This study investigated the major S. pyogenes strains responsible for infections in Türkiye and their susceptibility to beta-lactam and macrolide antibiotics.

Methods

We determined the minimum inhibitory concentration using the penicillin gradient test and performed emm typing and DNA fingerprinting via pulsed-field gel electrophoresis (PFGE) to analyze the clonal spread of 92 S. pyogenes strains isolated from two hospitals in Türkiye between 2020 and 2022.

Results

Our findings revealed the predominant S. pyogenes strains causing infections in the population and provided insights into the epidemiological relatedness of these drug-resistant strains. This study also evaluated the correlation between emm typing and PFGE in tracking S. pyogenes epidemiology. In this study, the current resistance patterns of S. pyogenes strains in Türkiye identified erythromycin resistance in a few strains, but no resistance to penicillin was detected.

Conclusions

This study revealed that emm types 1, 12 and 89 as S. pyogenes strain genotypes were responsible for epidemic infections in Türkiye. PFGE genotyping and emm typing were found to provide better phylogenetic classification in the investigation of S. pyogenes epidemiology.

查看原文本刊更多论文

基耶病毒中化脓性链球菌的耐药性及流行病学模式。

背景：在全球范围内，耐药的A组溶血链球菌仍然是重要的感染性病原体。本研究调查了基耶病毒感染的主要化脓性葡萄球菌菌株及其对-内酰胺类和大环内酯类抗生素的敏感性。方法：采用青霉素梯度试验确定最低抑菌浓度，并采用脉冲场凝胶电泳（PFGE）进行emm分型和DNA指纹图谱分析2020 - 2022年在泰国两家医院分离的92株化脓性链球菌的克隆传播情况。结果：我们的发现揭示了在人群中引起感染的主要化脓性葡萄球菌菌株，并为这些耐药菌株的流行病学相关性提供了见解。本研究还评估了emm分型与PFGE在追踪化脓性链球菌流行病学中的相关性。在本研究中，猩红热杆菌中化脓性链球菌目前的耐药模式发现少数菌株对红霉素耐药，但未发现对青霉素耐药。结论：emm 1型、12型和89型为产化脓性链球菌基因型，是引起鼠疫流行的主要原因。PFGE基因分型和emm分型在化脓链球菌流行病学研究中提供了较好的系统发育分类。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Infection and Public Health PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH -INFECTIOUS DISEASES

CiteScore

13.10

自引率

1.50%

发文量

203

审稿时长

96 days

期刊介绍： The Journal of Infection and Public Health, first official journal of the Saudi Arabian Ministry of National Guard Health Affairs, King Saud Bin Abdulaziz University for Health Sciences and the Saudi Association for Public Health, aims to be the foremost scientific, peer-reviewed journal encompassing infection prevention and control, microbiology, infectious diseases, public health and the application of healthcare epidemiology to the evaluation of health outcomes. The point of view of the journal is that infection and public health are closely intertwined and that advances in one area will have positive consequences on the other. The journal will be useful to all health professionals who are partners in the management of patients with communicable diseases, keeping them up to date. The journal is proud to have an international and diverse editorial board that will assist and facilitate the publication of articles that reflect a global view on infection control and public health, as well as emphasizing our focus on supporting the needs of public health practitioners. It is our aim to improve healthcare by reducing risk of infection and related adverse outcomes by critical review, selection, and dissemination of new and relevant information in the field of infection control, public health and infectious diseases in all healthcare settings and the community.