Pseudocellulitis in the Setting of Pemetrexed Treatment for Non-Small Cell Lung Cancer

IF 1.6 4区 医学 Q3 DERMATOLOGY
Cassidy M. Nguyen, Jake C. Robertson, Adam Cardenas, Edgar Martinez, Brett H. Keeling, Khang D. Nguyen
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引用次数: 0

Abstract

Pemetrexed is a chemotherapeutic, antimetabolite agent that has been used in oncology to treat diseases such as metastatic non-small cell lung cancer and unresectable malignant pleural mesothelioma. Pemetrexed use may result in pseudocellulitis, which presents as poorly demarcated patches or plaques with erythema, edema, warmth, and tenderness. These lesions can present unilaterally or bilaterally on the lower extremities. The histologic appearance includes vacuolar interface dermatitis, squamous metaplasia of eccrine coils and ducts, sparse mixed neutrophilic and lymphocytic interstitial inflammatory infiltrate, and widened subcutaneous fibrous septa with cystic fat degeneration. We present the case of a 58-year-old woman with non-small cell lung cancer and pemetrexed-induced pseudocellulitis with distinctive histological features. The clinical appearance of patients with this hypersensitivity condition may mimic cellulitis, emphasizing the importance of increased awareness and consideration of pseudocellulitis in the differential diagnosis of patients on chemotherapy to avoid unnecessary hospitalization and treatment.

培美曲塞治疗非小细胞肺癌的假性蜂窝细胞炎。
培美曲塞是一种化疗、抗代谢药物,已被用于肿瘤治疗疾病,如转移性非小细胞肺癌和不可切除的恶性胸膜间皮瘤。培美曲塞的使用可能导致假性蜂窝织炎,表现为界限不清的斑块或斑块,伴有红斑、水肿、发热和压痛。这些病变可以单侧或双侧出现在下肢。组织学表现为空泡界面皮炎,胰腺管和小管鳞状化生,稀疏的嗜中性粒细胞和淋巴细胞间质性混合炎症浸润,皮下纤维间隔增宽伴囊性脂肪变性。我们提出的情况下,58岁的女性非小细胞肺癌和培美曲塞诱导假性蜂窝组织炎具有独特的组织学特征。这种超敏性疾病患者的临床表现可能与蜂窝织炎相似,强调在化疗患者的鉴别诊断中提高对假性蜂窝织炎的认识和考虑的重要性,以避免不必要的住院和治疗。
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来源期刊
CiteScore
3.20
自引率
5.90%
发文量
174
审稿时长
3-8 weeks
期刊介绍: Journal of Cutaneous Pathology publishes manuscripts broadly relevant to diseases of the skin and mucosae, with the aims of advancing scientific knowledge regarding dermatopathology and enhancing the communication between clinical practitioners and research scientists. Original scientific manuscripts on diagnostic and experimental cutaneous pathology are especially desirable. Timely, pertinent review articles also will be given high priority. Manuscripts based on light, fluorescence, and electron microscopy, histochemistry, immunology, molecular biology, and genetics, as well as allied sciences, are all welcome, provided their principal focus is on cutaneous pathology. Publication time will be kept as short as possible, ensuring that articles will be quickly available to all interested in this speciality.
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