The double-edged role of IL-18 in reproductive endocrine and reproductive immune related disorders

IF 4.8 2区医学 Q2 IMMUNOLOGY

International immunopharmacology Pub Date : 2025-02-06 DOI:10.1016/j.intimp.2024.113859

Jing Shan , Jie Ding , Da-Jin Li , Xiao-Qiu Wang

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引用次数: 0

Abstract

Interleukin (IL)-18 is one of the members of IL-1 family cytokines, it was originally named as interferon gamma (IFN-γ) inducing factor. IL-18 is a pleiotropic immune regulator and has a bidirectional regulatory effect on immunity. It exerts a potent pro-inflammatory effect by inducing the expression of IFN-γ, also has an important anti-inflammatory role. In recent years, IL-18 has received widespread attention and become a research hotspot. Previous studies have described the roles of IL-18 in the pathogenesis of many diseases. However, the biologic activities of IL-18 and its role in the reproductive endocrine and reproductive immune related diseases are still not well understood, such as endometriosis (EMS), recurrent spontaneous abortion (RSA), polycystic ovary syndrome (PCOS), and infertility, which are closely related to inflammation and immunity. Here, we reviewed the research progress of IL-18 in these diseases in the past few years. This article provides an overview of the latest knowledge about the roles of IL-18 in these diseases, with a view to providing new possibilities for the diagnosis and treatment of reproductive endocrine and reproductive immune related disorders.

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IL-18 在生殖内分泌和生殖免疫相关疾病中的双重作用。

白细胞介素(IL)-18是IL-1家族细胞因子的成员之一，最初被命名为干扰素γ (IFN-γ)诱导因子。IL-18是一种多效性免疫调节剂，对免疫具有双向调节作用。它通过诱导IFN-γ的表达发挥强大的促炎作用，也具有重要的抗炎作用。近年来，IL-18受到广泛关注，成为研究热点。以前的研究已经描述了IL-18在许多疾病的发病机制中的作用。然而，IL-18的生物学活性及其在生殖内分泌和生殖免疫相关疾病中的作用尚不清楚，如子宫内膜异位症（EMS）、复发性自然流产（RSA）、多囊卵巢综合征（PCOS）、不孕症等与炎症和免疫密切相关的疾病。本文就近年来IL-18在这些疾病中的研究进展进行综述。本文就IL-18在这些疾病中的作用的最新研究进展进行综述，以期为生殖内分泌和生殖免疫相关疾病的诊断和治疗提供新的可能性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International immunopharmacology 医学-免疫学

CiteScore

8.40

自引率

3.60%

发文量

935

审稿时长

53 days

期刊介绍： International Immunopharmacology is the primary vehicle for the publication of original research papers pertinent to the overlapping areas of immunology, pharmacology, cytokine biology, immunotherapy, immunopathology and immunotoxicology. Review articles that encompass these subjects are also welcome. The subject material appropriate for submission includes: • Clinical studies employing immunotherapy of any type including the use of: bacterial and chemical agents; thymic hormones, interferon, lymphokines, etc., in transplantation and diseases such as cancer, immunodeficiency, chronic infection and allergic, inflammatory or autoimmune disorders. • Studies on the mechanisms of action of these agents for specific parameters of immune competence as well as the overall clinical state. • Pre-clinical animal studies and in vitro studies on mechanisms of action with immunopotentiators, immunomodulators, immunoadjuvants and other pharmacological agents active on cells participating in immune or allergic responses. • Pharmacological compounds, microbial products and toxicological agents that affect the lymphoid system, and their mechanisms of action. • Agents that activate genes or modify transcription and translation within the immune response. • Substances activated, generated, or released through immunologic or related pathways that are pharmacologically active. • Production, function and regulation of cytokines and their receptors. • Classical pharmacological studies on the effects of chemokines and bioactive factors released during immunological reactions.