Dementia subtypes and suicidality: A systematic review and meta-analysis

IF 7.5 1区医学 Q1 BEHAVIORAL SCIENCES

Neuroscience and Biobehavioral Reviews Pub Date : 2025-02-01 DOI:10.1016/j.neubiorev.2024.105995

Eleanor Nuzum , Radvile Medeisyte , Roopal Desai , Anastasia Tsipa , Caroline Fearn , Aphrodite Eshetu , Georgina Charlesworth , Gavin R. Stewart , Sebastian J. Crutch , Céline El Baou , Suman Kurana , Emilie V. Brotherhood , Katie Flanagan , Alberto Salmoiraghi , Amy Kerti , Joshua Stott , Amber John

{"title":"Dementia subtypes and suicidality: A systematic review and meta-analysis","authors":"Eleanor Nuzum , Radvile Medeisyte , Roopal Desai , Anastasia Tsipa , Caroline Fearn , Aphrodite Eshetu , Georgina Charlesworth , Gavin R. Stewart , Sebastian J. Crutch , Céline El Baou , Suman Kurana , Emilie V. Brotherhood , Katie Flanagan , Alberto Salmoiraghi , Amy Kerti , Joshua Stott , Amber John","doi":"10.1016/j.neubiorev.2024.105995","DOIUrl":null,"url":null,"abstract":"<div><h3>Aims</h3><div>Recent research has highlighted a link between dementia and increased risk of suicidal ideation, suicide attempts and suicide deaths. Understanding the relative risk of suicide between subtypes of dementia is important for services to offer appropriate intervention.</div></div><div><h3>Method</h3><div>We searched five databases from inception to July 2023 for peer-reviewed publications reporting suicidal ideation, suicide attempt or death by suicide for at least two dementia subtypes. Meta-analyses compared suicidality between subtypes of dementia with Alzheimer’s Disease (AD).</div></div><div><h3>Results</h3><div>From 4983 studies identified, 12 met inclusion criteria. Pooling data, people with Vascular Dementia were significantly more likely to experience suicidal ideation (OR= 2.02 [95 % CI= 1.06;3.8]) and attempt suicide (OR=1.94 [95 % CI= 1.28;2.94]) than people with AD, but not die by suicide (OR= 1.05 [95 % CI= 0.69;1.59]). People with Dementia with Lewy Bodies were significantly more likely to report suicidal ideation (OR= 1.56 [95 % CI= 1.09;2.23]) than AD but not attempt suicide (OR= 1.12 [95 % CI= 0.83;1.50]). People with Frontotemporal Dementia were significantly more likely to attempt suicide (OR= 2.42 [95 % CI= 1.02;5.72]) than people with AD but not report suicidal ideation (OR= 1.67 [95 % CI= 0.34;8.33]). People with Mixed Dementia were significantly more likely to attempt suicide (OR= 2.83 [95 % CI= 1.52;5.27]) than people with AD but not report suicidal ideation (OR = 1.65 [95 % CI= 0.5;5.46]).</div></div><div><h3>Conclusions</h3><div>Further research is needed to understand what underlies the increased risks of suicidal ideation and suicide attempts for rarer subtypes.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"169 ","pages":"Article 105995"},"PeriodicalIF":7.5000,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neuroscience and Biobehavioral Reviews","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0149763424004640","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BEHAVIORAL SCIENCES","Score":null,"Total":0}

引用次数: 0

Abstract

Aims

Recent research has highlighted a link between dementia and increased risk of suicidal ideation, suicide attempts and suicide deaths. Understanding the relative risk of suicide between subtypes of dementia is important for services to offer appropriate intervention.

Method

We searched five databases from inception to July 2023 for peer-reviewed publications reporting suicidal ideation, suicide attempt or death by suicide for at least two dementia subtypes. Meta-analyses compared suicidality between subtypes of dementia with Alzheimer’s Disease (AD).

Results

From 4983 studies identified, 12 met inclusion criteria. Pooling data, people with Vascular Dementia were significantly more likely to experience suicidal ideation (OR= 2.02 [95 % CI= 1.06;3.8]) and attempt suicide (OR=1.94 [95 % CI= 1.28;2.94]) than people with AD, but not die by suicide (OR= 1.05 [95 % CI= 0.69;1.59]). People with Dementia with Lewy Bodies were significantly more likely to report suicidal ideation (OR= 1.56 [95 % CI= 1.09;2.23]) than AD but not attempt suicide (OR= 1.12 [95 % CI= 0.83;1.50]). People with Frontotemporal Dementia were significantly more likely to attempt suicide (OR= 2.42 [95 % CI= 1.02;5.72]) than people with AD but not report suicidal ideation (OR= 1.67 [95 % CI= 0.34;8.33]). People with Mixed Dementia were significantly more likely to attempt suicide (OR= 2.83 [95 % CI= 1.52;5.27]) than people with AD but not report suicidal ideation (OR = 1.65 [95 % CI= 0.5;5.46]).

Conclusions

Further research is needed to understand what underlies the increased risks of suicidal ideation and suicide attempts for rarer subtypes.

查看原文本刊更多论文

痴呆亚型与自杀：一项系统综述和荟萃分析。

目的：最近的研究强调了痴呆症与自杀意念、自杀企图和自杀死亡风险增加之间的联系。了解不同痴呆亚型之间自杀的相对风险对于提供适当干预的服务非常重要。方法：我们检索了5个数据库，从成立到2023年7月，检索了至少两种痴呆亚型的自杀意念、自杀企图或自杀死亡的同行评审出版物。荟萃分析比较了阿尔茨海默病（AD）痴呆亚型之间的自杀率。结果：在4983项研究中，12项符合纳入标准。汇总数据，血管性痴呆患者比AD患者更容易产生自杀意念（OR= 2.02 [95% CI= 1.06;3.8]）和企图自杀（OR=1.94 [95% CI= 1.28;2.94]），但不会死于自杀（OR= 1.05 [95% CI= 0.69;1.59]）。患有路易体痴呆的患者报告自杀意念（OR= 1.56 [95% CI= 1.09;2.23]）的可能性明显高于阿尔茨海默氏症患者，但没有企图自杀（OR= 1.12 [95% CI= 0.83;1.50]）。额颞叶痴呆患者企图自杀的可能性明显高于阿尔茨海默病患者（OR= 2.42 [95% CI= 1.02;5.72]），但没有自杀意念（OR= 1.67 [95% CI= 0.34;8.33]）。混合性痴呆患者企图自杀的可能性（OR= 2.83 [95% CI= 1.52;5.27]）明显高于无自杀意念的AD患者（OR= 1.65 [95% CI= 0.5;5.46]）。结论：需要进一步的研究来了解在罕见亚型中自杀意念和自杀企图风险增加的原因。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Neuroscience and Biobehavioral Reviews 医学-行为科学

CiteScore

14.20

自引率

3.70%

发文量

466

审稿时长

6 months

期刊介绍： The official journal of the International Behavioral Neuroscience Society publishes original and significant review articles that explore the intersection between neuroscience and the study of psychological processes and behavior. The journal also welcomes articles that primarily focus on psychological processes and behavior, as long as they have relevance to one or more areas of neuroscience.