Proteomics technologies in toxicity screening: a review

IF 15 2区环境科学与生态学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Environmental Chemistry Letters Pub Date : 2025-01-03 DOI:10.1007/s10311-024-01816-1

Yushi Jin, Zhejia Sun, April Z. Gu, Xiaohong Zhou

引用次数: 0

Abstract

The presence of natural and synthetic toxic compounds in the environment requires the development of advanced detection methods. Here we review proteomics technologies for toxicity screening, with focus on principles, current status, mass spectrometry-based proteomics, protein microarray, and in-frame tagging method. Concerning mass spectrometry-based proteomics, we detail liquid chromatography-tandem mass spectrometry, label-free quantification, and thermal proteome profiling. We discuss the integration of the latest advances in proteomics technologies, such as single-cell proteomics, data-independent acquisition, and multi-omics approaches.

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来源期刊

Environmental Chemistry Letters 环境科学-工程：环境

CiteScore

32.00

自引率

7.00%

发文量

175

审稿时长

2 months

期刊介绍： Environmental Chemistry Letters explores the intersections of geology, chemistry, physics, and biology. Published articles are of paramount importance to the examination of both natural and engineered environments. The journal features original and review articles of exceptional significance, encompassing topics such as the characterization of natural and impacted environments, the behavior, prevention, treatment, and control of mineral, organic, and radioactive pollutants. It also delves into interfacial studies involving diverse media like soil, sediment, water, air, organisms, and food. Additionally, the journal covers green chemistry, environmentally friendly synthetic pathways, alternative fuels, ecotoxicology, risk assessment, environmental processes and modeling, environmental technologies, remediation and control, and environmental analytical chemistry using biomolecular tools and tracers.